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Articles

Longitudinal multi-omics analysis identify multi-kingdom microbiome-host interaction dynamics and diagnostic biomarkers of postoperative infection after kidney transplantation

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By Lu Wang, Yan-yan Sun, Jin-An Zhou, Xiu-Li Wang, Li-Ping Guo, Lan Zhu, Wen-Zhi Guo, Hui Wang, Jia-Yin Yang, Lin Zhong, Gang Chen, Jie Zhao, Ning-Ning Liu, Yun-Xuan Guan, Ling-Xiang Kong, Yong-Jing Ma, Tu-Run Song, Si-Jun Wang, Ya-Hui Huang, Ruo-Lin Tao, Wen-Jun Shang
| Nature Verified
Abstract Despite recent progresses in microbiome and infection, the role of multi-kingdom gut microbiome in kidney transplantation (KT) infection remains unexplored. Here we performed a longitudinal and integrative multi-omics analysis of the gut microbiome, fecal metabolome and plasma metabolome in 169 KT recipients across 5 different transplantation centers, comprising discovery and validation cohorts.
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