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Ty’Tianna Clark on Muck Rack

Ty’Tianna Clark

As seen in: The Journal of Clinical Investigation
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Articles

Pathobiont-driven antibody sialylation through IL-10 undermines vaccination

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By Chih-Ming Tsai, Irshad A. Hajam, J.R. Caldera, Austin Chiang, Xin Du, Emi Suzuki, Fatemeh Askarian, Brian Lin Verified, Igor H. Wierzbicki, Angelica M. Riestra, Douglas J. Conrad, David Gonzalez, David González Verified, Cesia Gonzalez, Biswa Choudhruy, Ty’Tianna Clark
| The Journal of Clinical Investigation
Abstract The pathobiont Staphylococcus aureus (Sa) induces nonprotective antibody imprints that underlie ineffective staphylococcal vaccination. However, the mechanism by which Sa modifies antibody activity is not clear. Herein, we demonstrate that IL-10 is the decisive factor that abrogates antibody protection in mice. Sa-induced B10 cells drive antigen-specific vaccine suppression that affects both recalled and de novo developed B cells.
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