Tyween Jia Coutinho

Abstract Pertussis remains a major public health challenge due to the inability of current acellular vaccines to prevent Bordetella pertussis colonisation and transmission. The live-attenuated intranasal vaccine, BPZE1, has shown efficacy in protecting against infection following challenge with virulent B. pertussis, but the immune mechanisms underpinning this protective effect are poorly defined.

1 INTRODUCTION Acne vulgaris (AV) is an epidemic of chronic, multifactorial inflammatory skin disorders.1 Characterized by the formation of comedones, papules, pustules, nodules, and cysts, which are the consequence of inflammation and blockage of the hair follicles and their associated sebaceous gland.