Tze King Tan

Abstract Multiple myeloma is a hematological malignancy arising from immunoglobulin-secreting plasma cells. It remains poorly understood how chromatin rewiring of regulatory elements contributes to tumorigenesis and therapy resistance in myeloma. Here we generate a high-resolution contact map of myeloma-associated super-enhancers by integrating H3K27ac ChIP-seq and HiChIP from myeloma cell lines, patient-derived myeloma cells and normal plasma cells.

Abstract T-cell acute lymphoblastic leukemia (T-ALL) is a hematological malignancy arising from immature thymocytes. Unlike well-known oncogenic transcription factors, such as NOTCH1 and MYC, the involvement of chromatin remodeling factors in T-ALL pathogenesis is poorly understood. Here, we provide compelling evidence on how SWI/SNF chromatin remodeling complex contributes to human T-ALL pathogenesis.

Correction to: Leukemia https://doi.org/10.1038/s41375-023-01993-y, published online 17 August 2023 Following the publication of this article, the authors were made aware that the position of the enhancer locus identified in another study was incorrectly described. Prior to our study, Leon et al. had reported on the MYCN enhancer and annotated this position (hg19, Chr2:16,438,737-16,439,346)(Leon TE et al., Cancer Discovery, 2020: PMID 32349972) [1].