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UCB Biopharma SPRL

As seen in: Nature, Archives of Disease in Childhood, Frontiers
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Articles

An improved method for large scale generation and high throughput functional characterization of human iPSC-derived microglia

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By UCB Biopharma SPRL
| Frontiers
Irena Kadiu1* Manisha Padmakumar1 Steven Biesmans1* Jorge S. Valadas2 Jan Detrez2 Gaëlle Gillet2 Marie-Laure Clénet2 1Neuroinflammation Focus Area, UCB Biopharma SPRL, Belgium 2UCB Biopharma SPRL, Belgium The final, formatted version of the article will be published soon. Receive an email when it is updated Neuroscience drug discovery has faced significant challenges due to limited access to relevant human cell models and the translatability of preclinical findings to human pathophysiology.
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Divergent functional outcomes of NLRP3 blockade downstream of multi-inflammasome activation: Therapeutic implications for ALS

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By UCB Biopharma SPRL
| Frontiers
Marie-Laure Clénet1, James Keaney1, Gaëlle Gillet1, Jorge S. Valadas1, Julie Langlois1, Alvaro Cardenas1, Julien Gasser1 and Irena Kadiu1* 1UCB Biopharma SPRL, Belgium The final, formatted version of the article will be published soon. Receive an email when it is updated NOD-Like Receptor Family Pyrin Domain Containing (NLRP3) inflammasome modulation has emerged as a potential therapeutic approach targeting inflammation amplified by pyroptotic innate immune cell death.
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[18F]Difluorocarbene for Positron Emission Tomography - Nature

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By UCB Biopharma SPRL, Ft. Collins, Jeroen B. I, Natan J. W
| Nature Verified
Abstract The advent of total-body Positron Emission Tomography (PET) has vastly broadened the range of research and clinical applications of this powerful molecular imaging technology1. Such possibilities have accelerated progress in 18F-radiochemistry with numerous methods available to 18F-label (hetero)arenes and alkanes2.
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