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Articles by Udit Singhal
Integrative multi-region molecular profiling of primary prostate cancer in men with synchronous lymph node metastasis - Nature Communications
Abstract Localized prostate cancer is frequently composed of multiple spatially distinct tumors with significant inter- and intra-tumoral molecular heterogeneity. This genomic diversity gives rise to many competing clones that may drive the biological trajectory of the disease. Previous large-scale sequencing efforts have focused on the evolutionary process in metastatic prostate cancer, revealing a potential clonal progression to castration resistance.
Characterizing population-wide genomic risk distribution for development of a novel clinical-genomic risk system for prognostication in patients with clinically localized prostate cancer | Prostate Cancer and Prostatic Diseases
Abstract Genomic classifiers are endorsed by guidelines and commonly used to inform prognosis in prostate cancer. We aimed to understand the distribution of genomic risk within the validated staging collaboration for cancer of the prostate (STAR-CAP) and propose a system integrating genomic and clinicopathologic risk. We hypothesized that genomic heterogeneity would have implications on risk estimates and may inform treatment decisions.
Antibiotic prophylaxis for transperineal prostate biopsy? An unanswered question
2 Castellani D Pirola GM Law YXT et al. Infection rate after transperineal prostate biopsy with and without prophylactic antibiotics: results from a systematic review and meta-analysis of comparative studies. J Urol. 207: 25-34 Therefore, choosing a non-inferiority limit based on the rates of infection after a transrectal approach is erroneous and has the potential to substantially bias the results due to underpowering.
Overcoming Our Red Dots and Confronting Racism From Patients
Identify all potential conflicts of interest that might be relevant to your comment. Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. Err on the side of full disclosure.
Overtreatment and Underutilization of Watchful Waiting in Men With Limited Life Expectancy: An Analysis of the Michigan Urological Surgery Improvement Collaborative Registry
Objective To determine rates of watchful waiting (WW) vs treatment in prostate cancer (PCa) and limited life expectancy (LE) and assess determinants of management. Materials and Methods Patients diagnosed with PCa between 2012 and 2018 with <10 years LE were identified from the Michigan Urologic Surgery Improvement Collaborative registry. Multinomial logistic regression models were used to identify factors associated with management choice among NCCN low-risk PCa patients.
INTERNATIONAL JOURNAL OF MECHANICAL ENGINEERING AND TECHNOLOGY (IJMET) © IAEME Publication | https://iaeme.com/Home/journal/IJMET
Chief Editor Dr. M.V.S. Murali Krishna - Professor, Department of Mechanical Engineering, Chaitanya Bharathi Institute of Technology, Hyderabad, India Editorial Board Dr. G. Arthanareeswaran - Professor, Department of Chemical Engineering, National Institute of Technology, Tiruchirappalli, India Dr. R. Dilli Babu - Professor, Department of Industrial Engineering, Anna University, Tamilnadu, India Dr. Eman H.
Long Noncoding RNAs in Cancer: From Function to Translation
a protein complex that physically changes DNA architecture to allow or restrict access of regulatory proteins and transcription machinery to DNA. The function of chromatin remodelers is often carried out by epigenetic modifications using the energy of ATP hydrolysis. a class of non-coding RNAs that plays a role in enhancer DNA-mediated transcriptional regulation. eRNAs have been shown to recruit RNA polymerase II to these DNA regions to assist in the initiation of gene transcription.
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