Ulrike Mietzsch

Abstract Appropriate terminology and definitions of neonatal encephalopathy (NE), hypoxic-ischemic encephalopathy (HIE), and perinatal asphyxia (PA) remain controversial. Participant criteria used in therapeutic hypothermia (TH) trials are frequently used as case definitions for NE/HIE/PA but studies are inconsistent. This review aims to assess variations in terminology and case participant criteria between trials for NE/HIE/PA.

Abstract To assess the proportion of Level IV NICUs with post-hemorrhagic ventricular dilatation (PHVD) management pathways and compare the pathways. A survey was distributed to 49 Children’s Hospitals Neonatal Consortium (CHNC) Level IV NICUs. A summarized pathway was developed from written pathways. Survey response rate was 82%. Twelve (30%) NICUs have written pathways, 11 (28%) report informal consensus, and 17 (43%) lack consensus.

Research Article Open Access Introduction Neonatal encephalopathy (NE)—including hypoxic-ischemic encephalopathy (HIE)—remains a leading cause of neonatal mortality and long-term neurodevelopmental impairment worldwide.1,2 Despite advances in neonatal care, substantial variation persists in clinical management and many aspects of care still lack robust evidence from randomized controlled trials (RCTs).3 Although existing registries play a valuable role in hypothesis generation, quality...