Unitè des Aspergillus

Abstract Aspergillus flavus and Aspergillus fumigatus are important human pathogens that can infect the lung and cornea. During infection, Aspergillus dormant conidia are the primary morphotype that comes in contact with the host. As the conidial surface-associated proteins (CSPs) and the extracellular proteins during the early stages of growth play a crucial role in establishing infection, we profiled and compared these proteins between a clinical strain of A. flavus and a clinical strain of A.

Highlights • Aspergillus Idos contribute to de novo NAD+ biosynthesis and fungal growth • In conditions of tryptophan abundance, Aspergillus releases indole derivatives via Aro • Activation of lung AhR enhances harmful lung inflammation during fungal infection • Pharmacological induction of Ido in Aspergillus improves infection outcome Summary Indoleamine 2,3-dioxygenases (IDOs) degrade l-tryptophan to kynurenines and drive the de novo synthesis of nicotinamide adenine dinucleotide.