Unmesh Jadhav

Abstract Precise spatiotemporal and cell type-specific gene expression is essential for proper tissue development and function. Transcription factors (TFs) guide this process by binding to developmental stage-specific targets and establishing an appropriate enhancer landscape.

This paper is only available as a PDF. To read, Please Download here. ABSTRACT Genetic mutations or regulatory failure underlies cellular malfunction in many diseases including colorectal cancer (CRC) and Inflammatory bowel diseases (IBD). However, mutational defects alone fail to explain the complexity of such disorders.

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