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Urvi Nikhil Shroff on Muck Rack

Urvi Nikhil Shroff

As seen in: The Journal of Clinical Investigation
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Articles

Sparsentan improves glomerular hemodynamics, cell functions and tissue repair in a mouse model of FSGS

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By JCI Insight, Georgina Gyarmati, Urvi Nikhil Shroff, Audrey Izuhara
| The Journal of Clinical Investigation
ResearchNephrology Open Access | 10.1172/jci.insight.177775 JCI Insight. https://doi.org/10.1172/jci.insight.177775. Copyright © 2024, Gyarmati et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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Neuronally differentiated macula densa cells regulate tissue remodeling and regeneration in the kidney

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By Georgina Gyarmati, Urvi Nikhil Shroff, Anne Riquier-Brison, Dorinne Desposito
| The Journal of Clinical Investigation
Abstract Tissue regeneration is limited in several organs, including the kidney, contributing to the high prevalence of kidney disease globally. However, evolutionary and physiological adaptive responses and the presence of renal progenitor cells suggest an existing remodeling capacity.
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A new view of macula densa cell protein synthesis

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By Urvi Nikhil Shroff, Georgina Gyarmati, Audrey Izuhara, Sachin Deepak
| American Physiological Society
Macula densa (MD) cells, the tubular component of the juxtaglomerular (JG) apparatus (JGA), are crucial for the regulation of renal and glomerular hemodynamics via the tubuloglomerular feedback loop as well as renin release from the neighboring JG cells. Strategically positioned at the glomerular vascular pole, the MD cell plaque consists of approximately 20–25 highly specialized epithelial cells, present at the end of the thick ascending limb of the nephron (1, 2).
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