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Vasugi Nattarayan on Muck Rack

Vasugi Nattarayan

As seen in: The Journal of Clinical Investigation
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Articles

Inactivating the lipid kinase activity of PI3KC2β is sufficient to rescue myotubular myopathy in mice

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By JCI Insight, Xènia Massana-Muñoz, Marie Goret, Vasugi Nattarayan
| The Journal of Clinical Investigation
Abstract Phosphoinositides (PI) are membrane lipids that regulate signal transduction and vesicular trafficking. X-linked centronuclear myopathy (XLCNM), also called myotubular myopathy, results from loss-of-function mutations in the Mtm1 gene, which encodes the myotubularin phosphatidylinositol 3-phosphate (PtdIns3P) lipid phosphatase. No therapy for this disease is currently available.
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