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Vicky Liu

As seen in: Medium, MDPI, BioRxiv, Cell Press, BiggerPockets, Lexology, Yale Daily News, The Fashion Law, Daily Journal (Los Angeles and San Francisco), LexBlog and
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Articles

Nuclear speckle proteins form intrinsic and MALAT1-dependent microphases

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By Min Kyung Shinn, Dylan T. Tomares, Vicky Liu, Avnika Pant, Yuanxin Qiu, Andreas Vitalis, Yuna M. Ayala, Kiersten M. Ruff, Gregory W. Strout, Matthew Lew, Kannanganattu V. Prasanth, Rohit V. Pappu
| Cell Press Verified
Keywords microphase separation intrinsically disordered regions nuclear speckles serine/arginine-rich splicing factors RNA binding proteins macrophase separation LLPS TDP-43 RRMs emulsions of microphases block copolymers Introduction In metazoan cells, nuclear speckles function as hubs that regulate key steps of gene expression.1,2,3,4,5,6,7,8 Speckles are enriched in RNA-binding proteins that contribute to pre-mRNA splicing.8,9,10,11,12,13 Splicing factor activities are regulated by...
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An HBS Discussion Group Breaks Up

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By Vicky Liu
| The Harbus
Vicky Liu 28 minutes ago 2 min read It’s not you. It’s all of us. Member 1: Hey. Member 2: Hi. Member 3: Hello. Member 4: I’m sorry for being late. I overslept. Should we start with FIN 1 today? Member 5: Sorry I was also late. I was pitching my AI startup to a VC in London, and the call went over because we were riffing on API infrastructure. Member 6: Me, too. Not the call part, but the remorse part. I was thinking hard about the best way to put this. Here goes. I can’t come to these anymore.
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Molecular grammars of predicted intrinsically disordered regions that span the human proteome

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By Kiersten M. Ruff, Matthew King, Alexander Ying, Vicky Liu, Avnika Pant, Whitney E. Lieberman, Min Kyung Shinn, Xiaolei Su, Cigall Kadoch, Rohit V. Pappu
| Cell Press Verified
Keywords intrinsically disordered regions molecular grammars subcellular localization biomolecular condensates transcriptional regulation RNA polymerase cancer Introduction Eukaryotic proteomes are composed of proteins with folded domains1 and intrinsically disordered regions (IDRs).2,3,4,5,6,7,8 IDRs are implicated in a range of molecular functions and cellular processes.3,9,10,11,12,13,14 The amino acid alphabet is used in a biased manner,8,9,10 and a subset of this non-random alphabet is...
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