Viral Populations

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Abstract SARS-CoV-2 variants of interest and concern will continue to emerge for the duration of the COVID-19 pandemic. To map mutations in the receptor-binding domain (RBD) of the spike protein that affect binding to angiotensin-converting enzyme 2 (ACE2), the receptor for SARS-CoV-2, we applied in vitro evolution to affinity-mature the RBD.

Enteroviruses infect millions of people every year and have been associated with a wide spectrum of acute diseases, ranging from mild febrile illness to severe disease. Enteroviruses can also trigger chronic diseases through persistent infections. 1 Alidjinou EK Sané F Engelmann I Geenen V Hober D Enterovirus persistence as a mechanism in the pathogenesis of type 1 diabetes. Discov Med.