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Virginia Guarani on Muck Rack

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By Mark P. Jedrychowski, Elma Zaganjor, Virginia Guarani, Steven Gygi, J. Wade Harper, Marcia C. Haigis, Koji Nagasawa, Christian Münch, Yingjie Xu, Kyle Satterstrom, Seungmin Jeong, Sebastian D. Hayes, F. Sejal Vyas, Alison E. Ringel
| secure.jbs.elsevierhealth.com
Open in Who Shared Issue with article?

QIL1 mutation causes MICOS disassembly and early onset fatal mitochondrial encephalopathy with liver disease

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By Institut Cochin, Virginia Guarani, Claude Jardel, GHU Pitié-Salpêtrière
| eLife
Recommended revisions: 1) The authors could have tried to gain more mechanistic insight into how essential QIL1 is in MICOS formation by for example, attempt suppression of the deleterious phenotype in QIL1-deficient fibroblasts by overexpression of some of the other MICOS subunits. Or, does QIL1 overexpression induces any changes in MICOS formation? This would help understanding whether QIL1 has a regulatory role in MICOS formation.
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