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Virpi Ahola

As seen in: Nature
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Articles

Single-nucleus epigenomic profiling of the adult human central nervous system unveils epigenetic memory of developmental programs

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By Mukund Kabbe, Eneritz Agirre, Karl E Carlstrom, Ozge Dumral, Fabio Pohl, Nicolas Ruffin, David van Bruggen, Mandy Meijer, Luise A. Seeker, Nadine Bestard-Cuche, Alex R Lederer, Jilin Zhang, Virpi Ahola, Steven Goldman Verified, Erik Edstrom, Lisa Arvidsson, Marek Bartosovic, Maja Jagodic, Anna Williams, Gonçalo Castelo-Branco, Yuk Kit Lor, Tiago Holm Moreira
| Nature Verified
Abstract Neural cells in the adult human central nervous system (CNS) display extensive transcriptional heterogeneity. How different layers of epigenetic regulation underpin this heterogeneity is poorly understood. Here we profile, at the single-nuclei epigenomic level, distinct regions of the adult human CNS, for chromatin accessibility and simultaneously for the histone modifications H3K27me3 and H3K27ac.
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Ecological and genetic basis of metapopulation persistence of the Glanville fritillary butterfly in fragmented landscapes

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By Ilkka Hanski, Torsti Schulz, Swee Chong Wong, Virpi Ahola
| Nature Verified
In the Åland islands, the Glanville fritillary inhabits dry meadows that have at least one of the two larval host plant species, the ribwort plantain (Plantago lanceolata) or the spiked speedwell (Veronica spicata)25,36. The habitat patches are small: the median size is 0.06?ha, and only 1% are greater than 2?ha. We have mapped the entire Åland Islands, an area of 50 × 70?km, for the habitat patches during two periods, in 1993 and 1998–1999. The first survey yielded ca.
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