Vishal Oza

Abstract Antigen compartmentalization is known to influence CD4 and CD8 T cell recognition but its impact on immune responses to different antigens expressed by the same pathogen is poorly understood. By tracking the clonal CD4 T cell response to a single epitope shuttled between different virulence proteins of Citrobacter rodentium, we found that response magnitude and quality depended on antigen localization.

1. Introduction Behavior-Driven Development (BDD) has long served as a bridge between technical teams and business stakeholders, aligning software features with user expectations through collaborative scenarios. However, as AI and LLM-driven systems evolve, the traditional boundaries of BDD must expand to accommodate context-rich, adaptive behaviors.

Abstract Background: Alzheimer's disease is the most common cause of dementia and is characterized by amyloid-β plaques, tau neurofibrillary tangles, and neuronal loss. Although neuronal loss is a primary hallmark of Alzheimer's disease, it is known that non-neuronal cell populations are ultimately responsible for maintaining brain homeostasis and neuronal health through neuron-glia and glial cell crosstalk.