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W. Barchet

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Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity

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By P. Gao, Y. F. Wu, M. Ascano, W. Barchet
| ScienceDirect Verified
Under a Creative Commons license open access Previous Next Keywords methionine antitumor immunity cGAS methylation SUV39H1 Introduction Cytoplasmic DNA is a danger signal and is sensed by cyclic GMP-AMP synthase (cGAS), which produces the second messenger cGAMP,1,2,3,4 and consequently activates the STING (also known as MITA, ERIS, and MPYS)-TBK1-IRF3-type I interferon (IFN) pathway.5,6,7,8 The cGAS-STING pathway has essential roles in innate immune response and cancer immunity.9 Activation...
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