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Waaqo Daddacha on Muck Rack

Waaqo Daddacha

As seen in: MDPI, Cell Press
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Articles

Viral Particle-Mediated SAMHD1 Depletion Sensitizes Refractory Glioblastoma to DNA-Damaging Therapeutics by Impairing Homologous Recombination

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By Waaqo Daddacha, Kristen Carver, Edidiong Usoro, Dominique Monroe
| MDPI
Open AccessArticle by Waaqo Daddacha 1,2,*, Dominique Monroe 1,2, Kristen Carver 1,3, Edidiong R. Usoro 1,2, Ahmet Alptekin 2, Hongyan Xu 3, Satoru Osuka 4, Ali S.
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SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination

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By Allyson E. Koyen, Amanda J. Bastien, PamelaSara E. Head, Waaqo Daddacha
| Cell Press Verified
SAMHD1 Localizes to DSBs in Response to DNA Damage SAMHD1 Promotes HR and DNA End Resection Independent of Its dNTPase Activity SAMHD1 Interacts in a Complex with CtIP in Response to DNA Damage SAMHD1 Recruits CtIP to DNA Damage Sites and Chromatin in Response to DNA Damage and Promotes DNA End Resection through Its Interaction with CtIP Targeting SAMHD1 with Virus-like Particles Containing Vpx Sensitizes Cancer Cells to DSB-Inducing Agents Our findings reveal a dNTPase-independent function...
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