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Waghmare Lab

As seen in: Cell Press
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Articles

SFRP1 in Skin Tumor Initiation and Cancer Stem Cell Regulation with Potential Implications in Epithelial Cancers

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By Anushakti Nagar, Raghava R. Sunkara, Waghmare Lab, Rahul M. Sarate
| Cell Press Verified
Highlights • Loss of Sfrp1 accelerates murine skin tumor initiation and SCC progression • Sfrp1 loss enhances in vivo tumorigenic potential of murine skin CSCs • We found enhanced EMT and Sox-2 in Sfrp1−/− murine skin SCC • Sfrp1 and Sox-2 are inversely correlated in multiple human epithelial cancers Summary Wnt signaling is involved in the regulation of cancer stem cells (CSCs); however, the molecular mechanism involved is still obscure.
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