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Wang Yinuo on Muck Rack

Wang Yinuo

As seen in: Nature, China Daily (English)
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Articles

Nrf2 activation by the monocarbonyl curcumin derivative GO-Y015 confers cellular protection against arsenite toxicity by reducing intracellular arsenic levels

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By Tanvir Islam, Hiroki Taguchi, Hiroyuki Yamakoshi, Wang Yinuo, Hiroyuki Shibata, Yoshiharu Iwabuchi, Takashi Toyama, Yoshiro Saito
| Nature Verified
Abstract Curcumin, a bioactive phenolic compound derived from turmeric, attenuates heavy metal toxicity, including inorganic arsenite (As(III)), via activation of the Nrf2–Keap1 signaling pathway; however, its low solubility and stability limit its bioactivity. To address these limitations, we synthesized curcumin derivatives and investigated the cytoprotective effects of a monocarbonyl analog, GO-Y015.
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