Hiroki Taguchi on Muck Rack

Hiroki Taguchi

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Articles

Increase in Sialylated EGFR Levels by Arsenite Enhances EGF-Dependent EGFR Phosphorylation

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By Daigo Sumi, Hiroki Taguchi, Saho Nakahira
| Wiley Online Library Verified
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request.
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Nrf2 activation by the monocarbonyl curcumin derivative GO-Y015 confers cellular protection against arsenite toxicity by reducing intracellular arsenic levels

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By Tanvir Islam, Hiroki Taguchi, Hiroyuki Yamakoshi, Wang Yinuo, Hiroyuki Shibata, Yoshiharu Iwabuchi, Takashi Toyama, Yoshiro Saito
| Nature Verified
Abstract Curcumin, a bioactive phenolic compound derived from turmeric, attenuates heavy metal toxicity, including inorganic arsenite (As(III)), via activation of the Nrf2–Keap1 signaling pathway; however, its low solubility and stability limit its bioactivity. To address these limitations, we synthesized curcumin derivatives and investigated the cytoprotective effects of a monocarbonyl analog, GO-Y015.
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