Wazim Mohammed Ismail

Abstract Senescent cells promote tissue dysfunction in part through the senescence-associated secretory phenotype (SASP)1. Cytosolic mitochondrial nucleic acids activate innate immune signalling to initiate this inflammatory programme2,3. Here we show that mitochondrial metabolism provides a second layer of control that enables execution of the inflammatory programme.

Communication Biololgy 10.1038/s42003-023-04571-1 Post-print Mice, Animals, Nuclear Proteins, Transcription Factors, Cellular Reprogramming, Enhancer Elements, Genetic, Chromatin, Epigenomics, Data integration yes Mohammed Ismail, Wazim; Mazzone, Amelia; Ghiraldini, Flavia G; et al., "Macroh2a Histone Variants Modulate Enhancer Activity to Repress Oncogenic Programs and Cellular Reprogramming" (2023). Faculty and Staff Publications. 5635. https://digitalcommons.library.tmc.edu/baylor_docs/5635

Abstract Durable response to chimeric antigen receptor T (CART) cell therapy remains limited in part due to CART cell exhaustion. Here, we investigate the regulation of CART cell exhaustion with three independent approaches including: a genome-wide CRISPR knockout screen using an in vitro model for exhaustion, RNA and ATAC sequencing on baseline and exhausted CART cells, and RNA and ATAC sequencing on pre-infusion CART cell products from responders and non-responders in the ZUMA-1 clinical trial.