Wei Du on Muck Rack

Wei Du

Verified
Hong Kong
As seen in: CNA (Channel NewsAsia), Environmental Health Perspectives, AIChE Journal, British Journal of Cancer, Color Research & Application, Nature, Wiley Online Library, Cambridge University Press & Assessment, PLOS, PLOS ONE, ScienceDirect and
Intl Emmy nominee @ChannelNewsAsia 🎥 | @OneWM Journo of the Year | Chongqing roots, HK home, a lap around the world in between | Wonk @❤, honesty is underrated
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Articles

Metabolic alterations in the tumor microenvironment influence the anti-tumor immune function of CD8 + T cells via epigenetic modifications

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By YaRu Liu, Wei Du Verified, Weimin Deng
| Taylor & Francis Online
Abstract Metabolic reprogramming within the tumor microenvironment (TME) is a pivotal driver of CD8+ T cell dysfunction in cancer. Tumor cells outcompete T cells for essential nutrients, including glucose and amino acids, while accumulating immunosuppressive metabolites such as lactate and 2-hydroxyglutarate.
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Gut microbiota-derived lysine phenylacetylation impairs mitochondrial function and is alleviated by SIRT3

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By Wei Du Verified, Jun-Yu Xu, Yufeng Li, Mingya Zhang, Yidan Huang, Shaoqian Zhao, Ying Zhou, Lei Zhao, Kexin Xu, Linhui Zhai, Wensi Zhao, Jia Liu, Jiahui Ni, Junxiao Dai, Tianxian Liu, Jie Hong, Haowen Jiang, Shuliang Zhao, Jian Zhang, Lu Zhou, Bin-Cheng Yin, Rui-Xin Liu, Jingya Li, Bang-Ce Ye, Minjia Tan, Ji-Qiu Wang
| Cell Metabolism Verified
Keywords lysine phenylacetylation SIRT3 MASLD/MASH mitochondrial function gut microbiota proteomics post-translational modification HSP60 phenylalanine phenylacetic acid Get full text access Log in, subscribe or purchase for full access. References 1. Kamada, N. ∙ Seo, S.U. ∙ Chen, G.Y. ... Role of the gut microbiota in immunity and inflammatory disease Nat. Rev. Immunol. 2013; 13:321-335 2. Henao-Mejia, J. ∙ Elinav, E. ∙ Jin, C.C. ...
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Clonal Hematopoiesis and CAR T Cell Therapy: From Biological Crosstalk to Clinical Implications

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By Wei Du Verified, Shunsuke Koga, Guang Yang
| Wiley Online Library Verified
1 Introduction Chimeric antigen receptor (CAR) T cell therapy has transformed outcomes for patients with relapsed or refractory hematologic malignancies [1]. By redirecting autologous T cells toward tumor associated antigens, it achieves durable remissions in patients with previously intractable diseases such as diffuse large B-cell lymphoma (DLBCL) [2], mantle cell lymphoma [3], follicular lymphoma [4], B-cell acute lymphoblastic leukemia [5], and multiple myeloma [6].
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