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Articles by Wei Gan
SLFN11 suppresses PD-L1 through CDK4-mediated BRD4 phosphorylation and ubiquitination by USP10/TRIM21
Abstract Pancreatic ductal adenocarcinoma (PDAC) exhibits a dismal prognosis driven by the interplay between dysregulated cell cycle progression in malignant cells and an immunosuppressive tumor microenvironment (TME). Proliferative PDAC subtypes are characterized by heightened immunosuppressive signatures and diminished cytotoxic CD8+ T cell infiltration.
Interpretable bulge-part descriptors identify region-specific pedestrian-level wind responses around T-form high-rise buildings
Abstract Protruding façade volumes (hereafter referred to as bulge parts) are frequently used in T‑form high‑rise building designs, yet their pedestrian‑level aerodynamic effects are challenging to evaluate across different configurations. This study develops physically interpretable derived descriptors, together with a framework combining computational fluid dynamics and statistical analysis.
Synthesis and Evaluation of Metal-Organic Framework Nanoarray Electrocatalyst for Oxygen Evolution Reaction: An Inquiry-Based Experiment for Undergraduates - Dialnet
The production of green hydrogen through electrochemical water electrolysis has been considered a critical pathway toward a sustainable energy future. However, its efficiency is severely limited by the kinetically sluggish anodic oxygen evolution reaction (OER), which drives the need to develop high-activity, nonprecious metal-based electrocatalysts.
TBL1X/TBL1XR1 govern β-cell identity through a PAX6-containing gene regulatory network
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Abstract A main mechanism of β-cell dysfunction in diabetes is loss of identity, controlled by transcription factors that induce identity gene expression and disallowed gene repression. How transcription factors facilitate simultaneous expression and repression is not fully understood, representing a knowledge gap in diabetes research.
By Alina Walth-Hummel, Celine Jouffe, Peter Weber, Karsten Motzler, Julia Geppert, Michael Sterr, Wei Gan, Iwona Szczerbinska, Ann-Christine König, Stefanie Hauck, Daniela Hass, Congcong Wang, Kenneth A. Dyar, James Lyon, Heiko Lickert, Carina Ämmälä, Stephan Herzig, Frances M. Ashcroft, Mostafa Bakhti, Patrick Macdonald, Maria Rohm, Raul Terron-Exposito
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Nature
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Genetics of skeletal proportions across two different populations
Keywords sitting height ratio height growth body proportion GWAS genome-wide association study fine-mapping gene set enrichment analysis gene prioritization trans-ancestry Introduction Human height has long been studied as a model polygenic phenotype due to its high heritability,1,2,3,4,5 polygenicity,6 and ease of accurate measurement.
Rational Design of Pentamethine Cyanine With Enhanced NIR-II Fluorescence and Photothermal Conversion Efficiency for Gram-Selective Antibacterial Applications
Y.Kong, J.Wang, W.Gan, Q.Jiang, Y.Yang, and F.Zhang, “Rational Design of Pentamethine Cyanine With Enhanced NIR-II Fluorescence and Photothermal Conversion Efficiency for Gram-Selective Antibacterial Applications.” Advanced Functional Materials (2026): e74922. https://doi.org/10.1002/adfm.74922 Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available in the supplementary material of this article.
Thermodynamic Modeling of Ionic Liquids with PC-SAFT: Quantifying the Impact of Association and Dipolar Terms
Cite Jump to ExpandCollapse Thermodynamics, Transport, and Fluid MechanicsFebruary 2, 2026 Thermodynamic Modeling of Ionic Liquids with PC-SAFT: Quantifying the Impact of Association and Dipolar Terms Click to copy article linkArticle link copied! Chenyang Zhu* Chenyang Zhu Beijing Key Laboratory of Process Fluid Filtration and Separation, College of Mechanical and Transportation Engineering, China University of Petroleum, Beijing 102249, China *Email: [email protected] Zilin Wu Zilin Wu...
Synergistic Resonance‐Enhanced Plasmon‐Free SERS in Few‐Layer Manganese Phosphorus Trichalcogenide
Conflict of Interest The authors declare no conflict of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description smll71953-sup-0001-SuppMat.docx16.6 MB Supporting Information References 1, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , et al., Chem. Soc. Rev. 2025, 54, 1453. 2, , , , , Mater. Today 2012, 15, 16. 3, , , , , , , Chem. Rev. 2023, 123, 1552.
Symmetry-Reduction Enhanced One-Dimensional Polarization-Sensitive Photodetectors for Multi-Functional Applications
Symmetry-Reduction Enhanced One-Dimensional Polarization-Sensitive Photodetectors for Multi-Functional Applications Due to its intrinsic structural anisotropy, one-dimensional van der Waals (1D vdW) materials can introduce distinct polarization photosensitivity. However, photodetectors based on 1D van der Waals material generally face challenges such as poor photosensitivity, narrow effective optical window, and uncompetitive dichroism.
Interpretable machine learning leverages proteomics to improve cardiovascular disease risk prediction and biomarker identification - Communications Medicine
Abstract Cardiovascular diseases (CVDs) rank amongst the leading causes of long-term disability and mortality. Predicting CVD risk and identifying associated genes are crucial for prevention, early intervention, and drug discovery. The recent availability of UK Biobank Proteomics data enables investigation of blood proteins and their association with a variety of diseases. We sought to predict 10 year CVD risk using this data modality and known CVD risk factors.
Exploring the antimicrobial activity of fermented and non‐fermented cocoa bean shell extracts through metabolomics analysis and synergistic studies
INTRODUCTION Antimicrobial multidrug resistance (AMR) is a pressing global health issue exacerbated by the overuse and misuse of antibiotics across various sectors, including medicine, agriculture, livestock, and aquaculture.1 Although the development of new antibiotics is crucial for combating AMR, it has become increasingly difficult to bring new antibiotics to market, mainly due to the high costs involved and the exit of major pharmaceutical companies from this area.
TSF-MDD: A Deep Learning Approach for Electroencephalography-Based Diagnosis of Major Depressive Disorder with Temporal-Spatial-Frequency Feature Fusion
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Interspecific Competition Between Eotetranychus sexmaculatus Riley and Oligonychus biharensis Hirst (Acari: Tetranychidae)
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Is the Children’s 15-Minute City an Effective Framework for Enhancing Children’s Health and Well-Being? An Empirical Analysis from Western China
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Effective Antiviral Therapy Improves Immunosuppressive Activities in the Immune Microenvironment of Hepatocellular Carcinoma by Alleviating Inflammation and Fibrosis
1 Introduction The immune microenvironment (IME) refers to the microenvironment formed by immune cells and their products, which plays a crucial role in cancer development [1]. Comparative research on the IME of recurrent tumors (RT) and primary tumors (PT) provides valuable insights into tumor recurrence mechanisms, the impact of the host organmicroenvironment on tumors, and the effects of drug therapy after tumor resection.
Wind-Driven Dynamics Around Building Clusters: Impact of Convex and Concave Curvilinear Morphologies and Central Angles
1. Introduction Urban populations have surged since the early 21st century, leading to a boom in novel architectural forms in major cities, particularly in developing regions [1,2]. Among these, curvilinear configurations—where multiple building units are connected to form one or more curved building rows—have gained popularity in high-rise residential developments due to their aesthetic appeal and flexible spatial arrangement [3].
Induction of antiherbivore defense responses in poplars using a methyl jasmonate and mesoporous silica nanoparticle complex
DATA AVAILABILITY STATEMENT The data that support the findings of this study are openly available in NCBI Bioproject Number: PRJNA1005815. Other data generated and analyzed in this study are available from the corresponding author upon reasonable request.
Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults - Nature Communications
Abstract Elevated blood pressure (BP) is major risk factor for cardiovascular diseases (CVD). Genome-wide association studies (GWAS) conducted predominantly in populations of European ancestry have identified >2,000 BP-associated loci, but other ancestries have been less well-studied. We conducted GWAS of systolic, diastolic, pulse, and mean arterial BP in 100,453 Chinese adults. We identified 128 non-overlapping loci associated with one or more BP traits, including 74 newly-reported associations.
Secure Active Intelligent Reflecting Surface Communication against Colluding Eavesdroppers
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Construction of SnS2/TiO2 S-scheme heterostructure photocatalyst for highly efficient photocatalytic degradation of tetracycline hydrochloride
Construction of SnS2/TiO2 S-scheme heterostructure photocatalyst for highly efficient photocatalytic degradation of tetracycline hydrochloride In this study, the S-scheme heterostructure photocatalyst of SnS2/TiO2 (denoted as ST) ultrathin nanosheet-nanorod arrays with high efficiency for the degradation of tetracycline hydrochloride (TC-HCl) was successfully prepared by a two-step hydrothermal method.
Symmetry-Reduction Enhanced Polarization-Sensitive Photoresponse Based on One-Dimensional van der Waals Materials
RETURN TO ARTICLES ASAPPREVFunctional Inorganic...Functional Inorganic Materials and DevicesNEXT Wei Gan Institute of Physical Science and Information Technology and Information Materials and Intelligent Sensing Laboratory of Anhui Province, Anhui University, Hefei 230601, China , Yucheng Liu Institute of Physical Science and Information Technology and Information Materials and Intelligent Sensing Laboratory of Anhui Province, Anhui University, Hefei 230601, China , Xue Liu Institute of...
Amide and Multihydroxyl Complementary Tailored Metal-Organic Framework with Enhanced Glycan Affinity for Efficient Glycoproteomic Analysis
RETURN TO ARTICLES ASAPPREVBiological and Medic...Biological and Medical Applications of Materials and InterfacesNEXT Zi Yang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China , Wei Gan Department of Laboratory Medicine, West China Hospital,...
Hierarchical transactive power exchange method on expressways for EV energy supplement
1 Introduction Electric vehicles (EVs) have gained significant attention due to their environmentally friendly characteristics (Liu et al., 2018; Ban et al., 2019; Fang et al., 2021). To promote EV development, the governments have implemented a series of relevant policies, such as driving restrictions and purchase subsidies (Haddadian et al., 2015). Consequently, it is expected that the number of EVs increases rapidly (Shao et al., 2017; Park et al., 2022).
MRI Imaging of Seminal Vesicle Tuberculosis
Wei Gan,1,* Yan Bi,2,* Xuwen Fu,1 Jialu Wei,1 Min Qi,1 Jintang He,3 Xiang Li1 1Department of Radiology, Kunming Third People’s Hospital/Yunnan Clinical Medical Center for Infectious Diseases, Kunming, 650041, People’s Republic of China; 2Department of Radiology, The People’s Hospital of Lincang, Lincang, Yunnan, 677000, People’s Republic of China; 3Department of Surgery, Kunming Third People’s Hospital/Yunnan Clinical Medical Center for Infectious Diseases, Kunming, 650041, People’s...
Mechanisms of Linezolid Resistance in Mycobacteria
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Genetics of skeletal proportions in two different populations
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A multi-objective optimization model for the coordinated operation of hydropower and renewable energy
Benxi Liu1*, Zihan Peng1, Shengli Liao1, Tengyuan Liu1 and Jia Lu2 1Institute of Hydropower and Hydroinformatics, Dalian University of Technology, Dalian, China 2Hubei Key Laboratory of Intelligent Yangtze and Hydroelectric Science, China Yangtze Power Co Ltd, Yichang, Hubei, China The rapid growth of wind and solar energy sources in recent years has brought challenges to power systems.
Construction and application of computerized risk assessment model for supply chain finance under technology empowerment
Construction of the SCFR assessment model based on FSVM In supply chain finance, the credit risk of SMEs comes from both objective breach of contract and moral hazard and the objective breach of contract and moral hazard of their counterparties (leading enterprises in the supply chain). On the one hand, debt repayment capacity is influenced by the financial health and management of SMEs and their counterparties; on the other hand, the supply chain’s future prospects and competitive climate.
Field-induced spin reorientation in the N\'eel-type antiferromagnet ${\mathrm{MnPS}}_{3}$
Abstract Manipulation of spin orientation in magnetic material has been the focus of increasing research interest, as it brings fascinating perspectives with regard to the exploration of underlying magnetic interactions and the design of electronic devices. Here we report on the field-induced spin reorientation below Néel temperature in antiferromagnet MnPS3.
Achieving Carbon Neutrality through Urban Planning and Design
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
CT imaging of ejaculatory duct TB
Introduction Tuberculosis (TB) has become a global public health problem. According to the World Health Organisation,1 there were 10 million TB cases worldwide in 2018. TB is a multi-system and multi-organ disease, which most often occurs in the lungs but can also occur in extrapulmonary organs, known as extrapulmonary TB.
Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis
Abstract Atherosclerosis results from maladaptive inflammation driven primarily by macrophages, whose recruitment and proliferation drive plaque progression. In advanced plaques, macrophage death contributes centrally to the formation of plaque necrosis, which underlies the instability that promotes plaque rupture and myocardial infarction. Hence, targeting macrophage cell death pathways may offer promise for the stabilization of vulnerable plaques.
Genetic Predisposition to Type 2 Diabetes and Risk of Subclinical Atherosclerosis and Cardiovascular Diseases Among 160,000 Chinese Adults
Genetics/Genomes/Proteomics/Metabolomics Abstract In observational studies, type 2 diabetes is associated with two- to fourfold higher risk of cardiovascular diseases (CVD). Using data from the China Kadoorie Biobank (CKB), we examined associations of genetically predicted type 2 diabetes with CVD among ∼160,000 participants to assess whether these relationships are causal.
Genetic Predisposition to Type 2 Diabetes and Risk of Subclinical Atherosclerosis and Cardiovascular Diseases Among 160,000 Chinese adults
Original Research Genetic Predisposition to Type 2 Diabetes and Risk of Subclinical Atherosclerosis and Cardiovascular Diseases Among 160,000 Chinese adults Array, on behalf of the China Kadoorie Biobank Collaborative Group (members listed in the online supplemental materials) Abstract In observational studies, type 2 diabetes is associated with 2- to 4-fold higher risks of cardiovascular diseases (CVD).
High thermal conductivity of high-quality monolayer boron nitride and its thermal expansion
INTRODUCTION With increasing demand in miniaturization, thermal dissipation becomes critical for the performance, reliability, longevity, and safety of various products, such as electronic and optoelectronic devices, lithium ion batteries, and micromachines.
Directed Remote Lateral Metalation: Highly Substituted 2‐Naphthols and BINOLs by In Situ Generation of a Directing Group
As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re‐organized for online delivery, but are not copy‐edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors.
Exfoliation of ultrathin FePS3 layers as promising electrocatalyst for oxygen evolution reaction
Few-layer ternary FePS3 nanosheets, prepared via chemical vapor transport synthesis and ball-milling exfoliation, exhibit excellent electrocatalytic performance for oxygen evolution reaction in alkaline medium.
Synergistic Effect of Atomically Dual-metal Doped Catalyst for Highly Efficient Oxygen Evolution
The oxygen evolution reaction (OER) involving multi-step electron transfer is a challenging in water-splitting due to its sluggish kinetics. It is desirable to explore more efficient electro-catalysts with abundant elements.
Metal dependent motif transition in a self-assembled monolayer of bipyridine derivatives via coordination: An STM study
Low-dimensional molecular motifs with diversity developed via the on-surface chemistry are attracting growing interest for their potential in advanced nanofabrication. In this work, scanning tunneling microscopy was employed to investigate the in situ and ex situ metal coordinations between 4,4′-ditetradecyl-2,2′-bipyridine (bpy) and Zn( ii) or Cu( ii) ions at a highly oriented pyrolytic graphite (HOPG)/1-phenyloctane interface under ambient conditions.
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