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Weidong Hu on Muck Rack

Weidong Hu

As seen in: Nature, PLOS ONE, MDPI, Royal Society of Chemistry, Stem Cell Reports, Dove Medical Press, City of Hope, Optica, Chemistry World
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Articles

Inhibition of ADSS2-mediated de novo AMP biosynthesis re-sensitizes acute myeloid leukemia to BH3 mimetics

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By Xin He, Lei Zhang, Song-Bai Liu, Zheng Li, Haojie Dong, Genevieve Baker, Jinhui Wang, Zhilian Jia, Xiyuan Lu, Yi-Chun Lin, Zunsong Hu, Umesh Prasad Yadav, Meng Liu, Lianjun Zhang, Zhenhua Chen, Xiwei Wu, Jianjun Chen, Chun-Wei Chen, Stefano Tiziani, Weidong Hu, Ya-Huei Kuo, Sheng-Li Xue, Yong Zhang, Min Li, Guido Marcucci, Zhaohui Gu, J. Jefferson P. Perry, Yun Luo, Yaoqiu Zhu
| Nature Verified
Abstract De novo purine synthesis is required to maintain tumor growth; however, its impact on therapy resistance remains unclear. Here, through a dynamic BH3-priming-based CRISPR screen, we found that deletion of ADSS2, which encodes the adenylosuccinate synthase 2 enzyme essential for adenosine monophosphate (AMP) synthesis, re-sensitizes drug-resistant acute myeloid leukemia cells to venetoclax and a myeloid cell leukemia-1 (MCL1) inhibitor.
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Allosteric inhibition of RAN decreases miR-126 biogenesis in endothelial cells and controls acute myeloid leukemia growth

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By Melissa A. Valerio, Wenyuan Wei, HyunJun Kang, Ning Ma, Supriyo Bhattacharya, Genevieve Baker, Weidong Hu, Lianjun Zhang, Dinh Hoang, Jia Feng, Hongyu Zhang, Bin Zhang, Nagarajan Vaidehi, Guido Marcucci, J. Jefferson P. Perry
| Nature Verified
Abstract The small GTPase RAN plays a role in the biogenesis of mature miR-126, which is supplied by the bone marrow arterioles to leukemic stem cells (LSCs). MiR-126 supports the homeostasis of LSCs that initiate and maintain acute myeloid leukemia (AML).
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Human iPSC-derived neural progenitor cells rescue motor function and brain pathology in symptomatic Canavan disease mice

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By Natasha Jackson, Lizhao Feng, Jianfei Chao, Peng Ye, Qui Luong, Guihua Sun, Weidong Hu, Yanhong Shi, Kayla Galo
| Stem Cell Reports Verified
ArticleOnline now102785Open access 1Department of Neurodegenerative Diseases, Beckman Research Institute of City of Hope, 1500 E. Duarte Rd., Duarte, CA 91010, USA 2Department of Immunology and Theranostics, Beckman Research Institute of City of Hope, 1500 E.
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