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Activin a Secretion by Muscle-Repairing Macrophages Induces Heterotopic Ossification in Mice
Publication Date 3-2-2026 Journal Journal of Clinical Investigation DOI oi: 10.1172/JCI193797 PubMedCentral® Posted Date 3-2-2026 PubMedCentral® Full Text Version Post-print Abstract The immune system is not only essential for host defense, but it is also involved in tissue maintenance and disease pathogenesis. Macrophages play a key role in tissue repair, fibrosis, and tumorigenesis, but the mechanisms underlying their multifunctionality have not been fully explored.
Activin A secretion by muscle-repairing macrophages induces heterotopic ossification in mice
Abstract The immune system is not only essential for host defense, but it is also involved in tissue maintenance and disease pathogenesis. Macrophages play a key role in tissue repair, fibrosis, and tumorigenesis, but the mechanisms underlying their multifunctionality have not been fully explored. Here, we identified Mrep (Ly6ChiCX3CR1loPDPN+CD9+) as a crucial subset of macrophages for muscle regeneration after muscle injury.
The impact of Sanming’s healthcare reform on medical resource misallocation: based on synthetic control method
ORIGINAL RESEARCH article Volume 13 - 2025 | https://doi.org/10.3389/fpubh.2025.1671174 This article is part of the Research TopicPublic Health Outcomes: The Role of Social Security Systems in Improving Residents' Health WelfareView all 99 articles 1 Introduction The global misallocation of healthcare resources has become an ever-more pressing challenge confronting nations worldwide.
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