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Wenying Xian

As seen in: Cell Press, The European Heart Journal
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Articles

Aberrant Deactivation-Induced Gain of Function in TRPM4 Mutant Is Associated with Human Cardiac Conduction Block

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By Wenying Xian, Xin Hui, Hongmei Wang, Qinghai Tian
| Cell Press Verified
Gain of Function in TRPM4A432T Is Associated with Aberrant Deactivation and Lower Plasma Membrane Expression TRPM4’s Aberrant Deactivation Kinetics Are Independent of Glycosylation, cPKC-Dependent Phosphorylation, and Ca2+-Dependent Changes in PIP2 Levels The Bulkiness of the Amino Acid at Position 432 Contributes to TRPM4’s Channel Gating Behavior Mutations at Position 432 Change the Compactness of TRPM4’s Homology Region 3 Photolytic Release of Ca2+ and Measurement of [Ca2+]i Determination...
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Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes

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By Technische Universität München, Universität des Saarlandes, Zhifen Chen, Wenying Xian
| The European Heart Journal Verified
AbstractAims Cardiomyocytes (CMs) generated from human induced pluripotent stem cells (hiPSCs) are increasingly used in disease modelling and drug evaluation. However, they are typically a heterogeneous mix of ventricular-, atrial-, and nodal-like cells based on action potentials (APs) and gene expression. This heterogeneity and the paucity of methods for high-throughput functional phenotyping hinder the full exploitation of their potential.
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