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HIV-1–specific broadly neutralizing antibodies (bNAbs) can protect rhesus monkeys against simian-human immunodeficiency virus (SHIV) challenge. However, the site of antibody interception of virus and the mechanism of antibody-mediated protection remain unclear. We administered a fully protective dose of the bNAb PGT121 to rhesus monkeys and challenged them intravaginally with SHIV-SF162P3.
FiguresFigure 1Viral RNA in TissuesTissue viral RNA (log RNA copies /108 cell equivalents) across multiple tissues at necropsy in animals on days 1, 3, 7, or 10 following inoculation with SIVmac251. The colors on each plot reflect individual animals.
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