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Tissue origins and immune correlates of viral rebound in SIV-infected rhesus macaques after ART discontinuation
Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share This article has 0 eLetter . Abstract Most persons living with HIV-1 who discontinue antiretroviral therapy (ART) demonstrate viral rebound, but the tissue-level events that lead to rebound viremia remain poorly understood.
Am80-lipid nanoparticles serve as an enteric mucosal adjuvant following parenteral immunization with inactivated polio vaccine
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Enteric pathogens are a major contributor to the global disease burden, necessitating vaccines capable of inducing robust gastrointestinal mucosal immunity.
By Yentli E. Soto Albrecht, Oded Liran, Roddy M. Grieves, Behnaz Eshaghi, Erika Yan Wang, Sevinj Mursalova, Timothy A Forster, Ninaad Lasrado, Jinbi Tian, Dorin Artzi, Stacey Lin, Zongting Wu, Xin Yang, Wontaek Chung, Ilin Sadeghi, Johnny Garcia, Ziqi Chen, Olivia Sheridan, Alicia Lau, Bernardo A. Mainou, Kathryn Jones, Yi Liu, Dan Barouch, Aki Gurram, Ulrich von Andrian
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Science Magazine
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Initial sites of SIV rebound after antiretroviral treatment cessation in rhesus macaques - Nature Microbiology
Abstract The tissue origin(s) and the earliest viral dynamics of HIV rebound after antiretroviral therapy (ART) remain unclear. Here, using barcoded SIVmac239 in rhesus macaques (n = 24), we defined the distribution of barcode-specific viral RNA expression in tissues during ART (n = 6) and then assessed initial clonal rebound 5 and 7 days after ART cessation by identifying barcodes in individual tissues that exceeded the 99th percentile of the on-ART distribution (‘outliers’).
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