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Dan Barouch

As seen in: Color Research & Application, Nature, Wiley Online Library, PLOS, Flipboard, JAMA (The Journal of the American Medical Association), Science Magazine, The New England Journal of Medicine, BioRxiv, Cell Host & Microbe and
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Articles

Am80-lipid nanoparticles serve as an enteric mucosal adjuvant following parenteral immunization with inactivated polio vaccine

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By Yentli E. Soto Albrecht, Oded Liran, Roddy M. Grieves, Behnaz Eshaghi, Erika Yan Wang, Sevinj Mursalova, Timothy A Forster, Ninaad Lasrado, Jinbi Tian, Dorin Artzi, Stacey Lin, Zongting Wu, Xin Yang, Wontaek Chung, Ilin Sadeghi, Johnny Garcia, Ziqi Chen, Olivia Sheridan, Alicia Lau, Bernardo A. Mainou, Kathryn Jones, Yi Liu, Dan Barouch, Aki Gurram, Ulrich von Andrian
| Science Magazine Verified
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Enteric pathogens are a major contributor to the global disease burden, necessitating vaccines capable of inducing robust gastrointestinal mucosal immunity.
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Initial sites of SIV rebound after antiretroviral treatment cessation in rhesus macaques - Nature Microbiology

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By Brandon F. Keele, Charles Goodman, Randy Fast, Jeremy Smedley, Caralyn S. Labriola, Michael K. Axthelm, Dan Barouch, Jeffrey D. Lifson, Jorden L. Welker
| Nature Verified
Abstract The tissue origin(s) and the earliest viral dynamics of HIV rebound after antiretroviral therapy (ART) remain unclear. Here, using barcoded SIVmac239 in rhesus macaques (n = 24), we defined the distribution of barcode-specific viral RNA expression in tissues during ART (n = 6) and then assessed initial clonal rebound 5 and 7 days after ART cessation by identifying barcodes in individual tissues that exceeded the 99th percentile of the on-ART distribution (‘outliers’).
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Anti-IL-15 treatment reduces acute lentivirus inflammation and signaling in the brain

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By Daniel R. Ram, Raja Gopalakrishnan, Malika Aid, Kyle Kroll, Caitlin Davis, Marco M. Hefti, Kimberly L. Fiock, Christine M. Fennessey, Noe B. Mercado, Rhianna Jones, Griffin Woolley, Valerie Varner, Michelle Lifton, Steven E. Bosinger, Dan Barouch, Brandon F. Keele, R. Keith Reeves, C. Sabrina Tan, Jasmine Miftahof, Omar Aristizabal, Eunice Kayitare Gikundiro, Brook Tilahun, Yvette Umutoniwase, Kate Loidolt, Victoria Harper-Alexander
| Cell Reports Medicine Verified
Keywords HAND SIV IL-15 microglia neuroinflammation CNS immune response Introduction Despite advancements in viral suppression with antiretroviral therapies, HIV-associated neurocognitive disorder (HAND) remains an ongoing chronic health problem in approximately half of people living with HIV (PLWH) worldwide.1,2 HIV infects the brain within days during the acute phase of infection and causes neurological symptoms.3 Viral entry into the central nervous system (CNS) elicits an early immune...
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