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Articles by William Snell
Molecular determinants of species-specific gamete adhesion triggering HAP2-mediated membrane fusion
Abstract Species-specific adhesion of gametes is a prerequisite to cell fusion during fertilization, yet the underlying molecular mechanisms are not fully understood for any organism. In Chlamydomonas, the adhesion protein MAR1 chaperones the conserved fusogen HAP2 into a pre-fusion conformation on the mt− gamete and is the receptor for the adhesion protein FUS1 on the mt+ gamete. Here, we report the X-ray structure of the FUS1/MAR1 adhesion complex, showing that it forms a (FUS1/MAR1)2 dimer.
A lipid flippase shapes the ciliary membrane and is essential for ciliogenesis
Preoperative Computed Tomography Features as Predictors of Malignancy and Survival in Canine Adrenal Tumours
Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description vco70011-sup-0001-Table.docxWord 2007 document , 13 KB Table S1: Accuracy of CT features for predicting malignancy of adrenal tumours. References 1, , , et al., “Surgical Management of Adrenal Gland Tumors With and Without Associated Tumor Thrombi in Dogs: 40 Cases (1994–2001),” Journal of the American Veterinary Medical Association 223 (2003): 654–662.
The membrane topology problem inherent in ciliogenesis is solved by ciliary recruitment of a phospholipid flippase
Abstract The cilium is a slender cellular projection whose membrane transduces signals essential in development and homeostasis. Although assembly of the axonemal core of the organelle is well-studied, the mechanisms that underlie formation of the ~250 nm diameter ciliary membrane from oppositely curved 50-100 nm diameter pre-ciliary vesicles remain poorly understood.
MAR1 links membrane adhesion to membrane merger during cell-cell fusion in Chlamydomonas
Highlights • FUS1/GEX2 proteins mediate gamete adhesion in unicellular and multicellular plants • FUS1 on Chlamydomonas plus gametes binds directly to MAR1 on minus gametes • MAR1-FUS1 receptor pair formation is essential for gamete adhesion and fusion • MAR1 is biochemically and functionally associated with conserved fusogen HAP2 Summary Union of two gametes to form a zygote is a defining event in the life of sexual eukaryotes, yet the mechanisms that underlie cell-cell fusion during...
Economic Viability of Industrial Hemp in the United States: A Review of State Pilot Program
Economic Information Bulletin No. (EIB-217) 83 pp by Mark Tyler, Jonathan Shepard, David Olson, William Snell, Susan Proper, and Suzanne Thornsbury After a hiatus of almost 45 years, the 2014 Farm Bill reintroduced industrial hemp production in the United States through State pilot programs.
Transient Internalization and Microtubule-Dependent Trafficking of a Ciliary Signaling Receptor from the Plasma Membrane to the Cilium
Highlights • During signaling, a plasma membrane pool of ciliary receptors is internalized • In transit to cilia, internalized receptors align along cytoplasmic microtubules • Within minutes after internalization, receptors concentrate at the bases of the cilia • Receptors re-appear on the cell surface as they enter the ciliary membrane Summary , , 3 Mukhopadhyay S. Badgandi H.B. Hwang S.H. Somatilaka B. Shimada I.S. Pal K. Trafficking to the primary cilium membrane. Mol. Biol. Cell.
Mid-Semester Stress Busters
As students, we definitely take Grey Towers Castle for granted. Listed on the U.S. National Register of Historic Places and as a U.S. National Historic Landmark, the Castle is a great place to hang out. Are you musically inclined? Enter the Castle and enchant the entire building by playing on its grand piano. Take artsy pictures of the Castle’s immaculate architecture both inside and outside the building. My personal favorite Castle spots include the Mirror Room and the Greenhouse Room.
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