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Willie June Brickey on Muck Rack

Willie June Brickey

As seen in: The Journal of Biological Chemistry
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Articles

Isolates of Salmonella typhimurium circumvent NLRP3 inflammasome recognition in macrophages during the chronic phase of infection

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By David Cai, Jenny P Ting, Willie June Brickey
| The Journal of Biological Chemistry Verified
Inflammasome signaling results in cell death and release of cytokines from the IL-1 family, which facilitates control over an infection. However, some pathogens such as Salmonella typhimurium (ST) activate various innate immune signaling pathways, including inflammasomes, yet evade these cell death mechanisms, resulting in a chronic infection. Here we investigated inflammasome signaling induced by acute and chronic isolates of ST obtained from different organs.
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