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Willy Roque Barboza on Muck Rack

Willy Roque Barboza

As seen in: BioRxiv, The Journal of Clinical Investigation
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Articles

REGULATORY T CELLS PROTECT AGAINST ABERRANT REMODELING IN A MOUSE MODEL OF PULMONARY FIBROSIS

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By Aditi Murthy, Luis Rodriguez, Luis Rodríguez, Willy Roque Barboza, Yaniv Tomer
| BioRxiv
Abstract Regulatory T (Treg) cells are well recognized for their role in immune regulation; however, their role in tissue regeneration is not fully understood. This study demonstrates such a role of Tregs in a published preclinical murine model of spontaneous pulmonary fibrosis (PF) expressing a human PF related mutation in the Surfactant Protein-C (SP-C) gene (SFTPCI73T). Genetic crosses of SP-CI73T mice with Foxp3GFP and Foxp3DTR lines were utilized to study Treg behavior during PF development.
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Aberrant Transitional Alveolar Epithelial Cells Promote Pathogenic Activation of Lung Fibroblasts in Preclinical Fibrosis Modeling

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By Evan Hoffman, Willy Roque Barboza, Luis Rodriguez, Luis Rodríguez, Rachna Dherwani
| BioRxiv
Abstract Pulmonary fibrosis (PF) is a chronic progressive lung disease histopathologically characterized by fibrotic remodeling and the presence of pathological epithelial and mesenchymal cell populations in the distal lung parenchyma. Within the epithelial compartment, a subset of alveolar type 2 cells (AT2s) enter and persist in an aberrant transitional state. Whether and how these aberrant transitional cells participate in lung fibrosis is not known.
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PGF2α signaling drives fibrotic remodeling and fibroblast population dynamics in mice

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By JCI Insight, Luis Rodriguez, Luis Rodríguez, Willy Roque Barboza, Aditi Murthy
| The Journal of Clinical Investigation
ResearchPulmonology Open Access | 10.1172/jci.insight.172977 JCI Insight. https://doi.org/10.1172/jci.insight.172977. Copyright © 2023, Rodriguez et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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