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Wolfdieter Springer

As seen in: Nature, Cell Press
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Articles

N -of-1 investigational study of a novel antisense oligonucleotide drug in CHCHD10 -related ALS shows early signs of efficacy

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By Margot A. Cousin, Laurence Mignon, Jaimin Shah, Mercedes Prudencio, Tania F. Gendron, Angita Jain, Evan Udine, Marka van Blitterswijk, Erik H. Middlebrooks, Jens O Watzlawik, Wolfdieter Springer, Tejal Parekh, Zachary T. McEachin, Leonard Petrucelli, Björn Oskarsson, Aditi I. Dagli, Megan H. Donahue, Jany E. Dagher
| Cell Press Verified
Keywords amyotrophic lateral sclerosis antisense oligonucleotide CHCHD10 neurofilament light individualized therapy CAT Scale translation to patients Get full text access Log in, subscribe or purchase for full access. References 1. Bannwarth, S. ∙ Ait-El-Mkadem, S. ∙ Chaussenot, A. ... A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement Brain. 2014; 137:2329-2345 2. Kwan, J.Y. ∙ Lantz, C.I. ∙ Korobeynikov, V.A. ...
Open in Who Shared Issue with article?

The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness - Nature Communications

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By Xingxing Zhu, Yue Wu, Virginia Shapiro, Jie Sun, Wolfdieter Springer
| Nature Verified
Abstract Germinal center (GC) formation, which is an integrant part of humoral immunity, involves energy-consuming metabolic reprogramming. Rag-GTPases are known to signal amino acid availability to cellular pathways that regulate nutrient distribution such as the mechanistic target of rapamycin complex 1 (mTORC1) pathway and the transcription factors TFEB and TFE3. However, the contribution of these factors to humoral immunity remains undefined.
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