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Wote Amelo Rike

As seen in: Nature, MDPI, Flipboard, BioRxiv
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Articles

Extracellular vesicles from stem cells rescue cellular phenotypes and behavioral deficits in SHANK3-associated ASD neuronal and mouse models - Cell Death & Disease

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By Ashwani Choudhary, Idan Rosh, Yara Hussein, Shai Netser, Aviram Shemen, Taghreed Suliman, Wote Amelo Rike, Lilach Simchi, Boris Shklyar, Ahmad M. Abu-Akel, Assaf Zinger, Daniel Offen, Shlomo Wagner, Shani Stern
| Nature Verified
Abstract Extracellular vesicles (EVs) are lipid bilayer-enclosed structures that mediate intercellular communication by transferring diverse cargoes, including RNA and proteins. SHANK3, a synaptic scaffolding protein critical for synapse structure and function, is implicated in autism spectrum disorder (ASD) and Phelan-McDermid Syndrome (PMS). Early hyperexcitability in cortical neurons is a characterized endophenotype in ASD.
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Detecting suicide risk in bipolar disorder patients from lymphoblastoid cell lines genetic signatures

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By Omveer Sharma, Ritu Nayak, Liron Mizrahi, Wote Amelo Rike, Ashwani Choudhary, Hagit Sadis, Yara Hussein, Idan Rosh, Utkarsh Mani Tripathi, Aviram Shemen, Yam Stern, Alessio Squassina, Martin Alda, Shani Stern
| Flipboard
The over-the-counter antihistamine azelastine works against a range of respiratory infections, including the flu and RSV, according to German researchers. An over-the-counter nasal spray which has been used for years as a safe and effective treatment for seasonal allergies could potentially prevent …
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Predicting Suicide Risk in Bipolar Disorder patients from Lymphoblastoid Cell Lines genetic signatures

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By Liron Mizrahi, Wote Amelo Rike, Omveer Sharma, Ritu Nayak
| BioRxiv
Abstract This research investigates the genetic signatures associated with a high risk of suicide in Bipolar disorder (BD) patients through RNA sequencing analysis of lymphoblastoid cell lines (LCLs). By identifying differentially expressed genes (DEGs) and their enrichment in pathways and disease associations, we uncover insights into the molecular mechanisms underlying suicidal behavior.
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