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Wuqian Mai on Muck Rack

Wuqian Mai

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Articles

Adipocyte OX40L promotes adipose T cell activation and insulin resistance in obesity

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By Jianfeng Song, Qin Zeng, Xiaoxiao Sun, Limin Xie, Wanyu Hu, Fanqi Wang, Biling Huang, Ying Mei, Dandan Wang, Lan Xie, Xiang Xiao, Wei Liu, Willa A. Hsueh, Xian Li, Tuo Deng, Yayi Jiao, Jingpei Qiu, Yujin Ding, Wuqian Mai
| Nature Verified
Abstract T cells contribute critically to obesity-induced adipose inflammation and insulin resistance, yet the co-stimulatory signals that govern their activation in adipose tissue remain unclear. Here, we systematically profile co-stimulatory molecules in adipocytes and adipose tissue macrophages and identify OX40 ligand (OX40L) as the most robustly upregulated in obesity. OX40L is also elevated in adipocytes from obese humans.
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