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Wuqiang Zhan

As seen in: Cell Press
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Articles

TMEM63B functions as a mammalian hyperosmolar sensor for thirst

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By Wenjie Zou, Siqi Deng, Xingyu Chen, Jiamin Ruan, Huize Wang, Wuqiang Zhan, Jingxin Wang, zhiyong Liu, Zhiqiang Yan
| Cell Press Verified
Keywords thirst sensory receptors mechanically gated ion channel TMEM63B SFO hyperosmosensitive water homeostasis osmolarity interoception Get full text access Log in, subscribe or purchase for full access. References 1. Noda, M. ∙ Sakuta, H. Central regulation of body-fluid homeostasis Trends Neurosci. 2013; 36:661-673 2. Danziger, J. ∙ Zeidel, M.L. Osmotic homeostasis Clin. J. Am. Soc. Nephrol. 2015; 10:852-862 3. Gizowski, C. ∙ Bourque, C.W. The neural basis of homeostatic and anticipatory thirst Nat. Rev.
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Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody

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By Wuqiang Zhan, Zhenlin Yang, Gaowei Hu, Xiang Zhang, Youhua Xie, Zhenguo Chen
| Cell Press Verified
Highlights ● Conserved epitopes outside of the receptor binding motif (RBM) of SARS-CoV-2 spike RBD ● A bispecific single-domain antibody (bn03) broadly neutralizes SARS-CoV-2 variants ● Two arms of bn03 can bind simultaneously and synergistically to one RBD of spike trimer ● Inhalation of bn03 can effectively treat SARS-CoV-2 infection in hACE2 mice Summary The effectiveness of SARS-CoV-2 vaccines and therapeutic antibodies has been limited by the continuous emergence of viral variants, and...
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