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Wuyuan Lu

As seen in: Nature, PLOS, Frontiers, Cell Press
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Articles

Next-generation inhibitors of SARS-CoV-2 M pro overcome the deficiencies of Paxlovid

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By Gan Luo, Gang Wang, Chongbing Liao, Lianfeng Fan, jue zhang, Jie Rao, Junjie Zhang, Ziqiao Wang, Man Luo, Lu Lu, Wei Xu, Fan Wu, Xihui Gao, Wuyuan Lu, Baisen Zhong
| Nature Verified
Abstract It remains elusive to design peptidomimetic inhibitors of SARS-CoV-2 main protease (Mpro) refractory to multiple deficiencies of Paxlovid (ritonavir-boosted nirmatrelvir), pertaining mainly to E166X mutations-conferred drug resistance and inherent pharmacokinetic limitations to nirmatrelvir.
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Shigella infection is facilitated by interaction of human enteric α-defensin 5 with colonic epithelial receptor P2Y11 - Nature Microbiology

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By Dan Xu, Mengyao Guo, Stephen Bush, Tun Xu, Yaming Jiu, Wuyuan Lu, Philippe J. Sansonetti, Nathalie Sauvonnet
| Nature Verified
Abstract Human enteric α-defensin 5 (HD5) is an immune system peptide that acts as an important antimicrobial factor but is also known to promote pathogen infections by enhancing adhesion of the pathogens. The mechanistic basis of these conflicting functions is unknown.
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Mycobacterium tuberculosis cell-wall and antimicrobial peptides: a mission impossible?

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By Wuyuan Lu, Vivek P Chavda, Renato Gennaro, Yolanda M. Jacobo-Delgado
| Frontiers
Introduction The Mycobacterium tuberculosis (Mtb) cell wall is probably the most complex membrane of all bacteria. The architecture of this complex wall extends to a massive core comprised of peptidoglycans covalently attached via a linker unit to a linear galactofuran and to several strands of a highly branched arabinofuran, and mycolic acids. Mycolic acids are oriented perpendicular to the membrane plane and provide a lipid barrier, which is the main feature of this bacteria (1).
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