Xiake Hu on Muck Rack

Xiake Hu

As seen in: Nature, MDPI
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Articles

EZH2 deficiency suppresses colorectal cancer progression by inhibiting the mismatch repair pathway and consequently reducing extrachromosomal circular DNA formation

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By Quanpeng Qiu, Yi Ding, Jing Han, Xiaolong Guo, Jiaqi Zhang, Yue Chen, Xinzhu Xue, Xiake Hu, Tianyu Yu, Gaixia Liu, Haowei Zhang, Qixin Li, Xiang Li, Yinnan Chen
| Nature Verified
Abstract The malignant transition of colorectal cancer (CRC) is caused by the combined action of epigenetic dysregulation and genomic instability. It is well known that EZH2-directed H3K27me3 modification is one of the main contributors to tumorigenesis; however, how it affects the DNA mismatch repair (MMR) system and the genesis of extrachromosomal circular DNA (eccDNA) remains unknown.
Open in Who Shared Issue with article?

P53 Deficiency Accelerate Esophageal Epithelium Intestinal Metaplasia Malignancy

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By Gang Guo, Xiaolong Guo, Quanpeng Qiu, Xiake Hu
| MDPI
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
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