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Articles by Xiang Lu
Clinical outcomes of continuous versus intermittent linezolid infusion regimens: a systematic review and meta-analysis
Abstract Objective: We aimed to compare the clinical cure profile of linezolid administered as continuous infusion (CI) vs. intermittent infusion (II), to provide practicable evidence for optimizing linezolid dosing.
A system dynamics-based approach to multi-dimensional damage reduction mining regulation and strategy in open-pit coal mines
Abstract The environmental damage caused by open‑pit coal mining—including land excavation and occupation, groundwater disturbance, dust emissions, and carbon cycle imbalance—is not a collection of isolated phenomena but rather a systematically coupled ecological damage process driven by mining activities and mediated through pathway interactions among subsystems.
An untethered sub-gram flapping-wing flight system achieves sustained self-stabilizing and altitude-controlled flight
Abstract Insect-scale flapping-wing micro aerial vehicles offer substantial potential for applications such as search and rescue. However, stringent power and payload constraints at the sub-gram scale have precluded sustained untethered flight. Inspired by the high lift generated by full-circumferential rotor motion, this study presents a cross-shaped piezoelectric direct-drive V-wing structure.
The association of urinary xenoestrogens levels in pregnant women and their risk of missed miscarriage
Abstract Introduction: Environmental exposure to hormone-like compounds that mimic endogenous estrogens is widespread. Xenoestrogens, a class of endocrine-disrupting chemicals, may interfere with endocrine function and adversely affect pregnancy outcomes. However, their association with missed miscarriage remains unclear. This study investigated the association between urinary xenoestrogen concentrations and the risk of missed miscarriage.
Research on precision measurement methods for dynamic multi-objective roller tank lugs dimensions in shaft hoisting systems
Abstract Roller tank lugs are the guiding devices in vertical shaft hoisting systems, playing a crucial role in ensuring the stable operation of the hoisting equipment. Existing size measurement methods for roller tank lugs suffer from poor real-time performance and complex processing procedures. To address these issues, this paper proposes a real-time, multi-target size detection technology for roller tank lugs based on YOLOv8.
Autonomously Motile Nano-PROTACs Act as Protein-Sweeping Robots to Enhance Targeted Protein Degradation
, , , et al. “Autonomously Motile Nano-PROTACs Act as Protein-Sweeping Robots to Enhance Targeted Protein Degradation.” Advanced Materials (2026): e73991. https://doi.org/10.1002/adma.73991 Conflicts of Interest The authors declare no conflicts of interest Data Availability Statement The data presented in this work are available from the lead contact upon reasonable request.
A pathogen lncRNA secreted into rice sequesters a host miRNA for virulence
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Abstract Plants and animals respond to pathogens through pattern recognition receptor and Nod-like receptor proteins1. Pathogens commonly use protein effectors to suppress host immunity for successful infection2. However, the existence of non-protein effector classes remains comparatively understudied.
By Min He, Jia Xian Su, Xiaogang Zhou, Tuo Qi, Jiazheng Wang, Tianxin Zhang, Jinhua Chen, Mawsheng Chern, Youpin Xu, Xiang Lu, Qingqing Hou, Hongrui Liu, Wenfang Huang, Jiawei Liu, Shiying Li, Yunfei Zhu, Senyu Ran, Renju Liu, Mingliang Lei, Guosong Shu, Haicheng Liao, Junjie Yin, Xiaobo Zhu, Yongyan Tang, Long Wang, Qing Xiong, Jiali Liu, Yu Bi, yihua Yang, Hai Qing, Bingtian Ma, Jing Fan, Peng Qin, Yuping Wang, Jianming Wu, Wenming Wang, Shigui Li, Weitao Li, Jing Wang, Xuewei Chen
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Nature
Verified
The role of exosome derived miRNAs in inter-cell crosstalk among insulin-related organs in type 2 diabetes mellitus
Exosomes are small extracellular vesicles secreted by almost all cell types, and carry diverse cargo including RNA, and other substances. Recent studies have focused exosomal microRNAs (miRNAs) on various human diseases, including type 2 diabetes mellitus (T2DM) and metabolic syndrome (METS) which accompany the occurrence of insulin resistance.
In-Lake GHG Production Constrained by Lake DOM Mass Balance in a Boreal Catchment
1 Introduction Globally, lakes and rivers are hotspots for the lateral transport and atmospheric ventilation of terrestrially fixed carbon (C) (Cole et al., 2007; Pi et al., 2022; Rosentreter et al., 2021; Tranvik et al., 2009).
Characteristics of the rhizosphere microbial communities of different mulberry varieties in saline soil
Abstract Mulberry is a common crop with different varieties of resistance. Understanding the differences in rhizosphere soil microbial community characteristics among different salt-tolerant mulberry varieties in saline soils is important for the rational development and utilization of coastal saline soils.
Alternative splicing and differential gene expression during changes in endometrial receptivity in patients with recurrent implantation failure - Scientific Reports
Abstract Recurrent implantation failure (RIF) remains a major challenge in assisted reproductive technology, and the molecular mechanisms underlying endometrial receptivity are incompletely understood. This study aimed to comprehensively characterize transcriptomic alterations, including alternative splicing events (ASEs), differential gene expression (DEGs), and immune cell dynamics across different phases of endometrial receptivity in women with RIF.
Cell surface localization and function of the cell envelope proteinase derived from the lactic acid bacteria strains
Abstract Lactic acid bacteria (LAB) are renowned for their proteolytic systems, particularly cell envelope proteinases (CEPs), which hydrolyze caseins into peptides and amino acids essential for bacterial growth, flavor development, and bioactive peptide production. The protein hydrolysis system of LAB comprises cell envelope proteinases (CEPs), oligopeptide transport systems, and intracellular peptidases.
Toxicological Insights Into Multiple Pesticide Exposures in Red Swamp Crayfish (Procambarus clarkii): Molecular Mechanisms, Risk Assessments, and Future Perspectives for Aquaculture
Dan-Dan Bian College of Life Science and Agriculture Forestry, Qiqihar University, Qiqihar, China Jiangsu Key Laboratory for Bioresources of Saline Soils, Jiangsu Synthetic Innovation Center for Coastal Bio-Agriculture, Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection, School of Wetlands, Yancheng Teachers University, Yancheng, China Anhui Key Laboratory of Resource Insect Biology and Innovative Utilization, College of Life Sciences, Anhui...
Domestication of Tartary Buckwheat Shaped a Regulatory Module for Seedling Salt Tolerance by Targeting the Magnesium Transporter Gene FtMGT2
1 Introduction Crop domestication was a pivotal event in the development of our agriculture-based civilization.[1] Previous studies indicated that human-driven selection factors typically led to higher crop yields following domestication.[2] However, the content of secondary metabolites, such as hormones and flavonoids, in crops was frequently diminished during this process.[3, 4] Concomitantly, this reduction in secondary metabolites often compromises crop resistance to abiotic and biotic...
VEGFA‐centric angiogenic genetic variants drive hypertension and dyslipidaemia susceptibility in type 2 diabetes mellitus: A multilocus synergistic cohort study - Zuo - Diabetic Medicine - Wiley Online Library
CONFLICT OF INTEREST STATEMENT The authors declare that they have no potential conflicts of interest with respect to the research, authorship and/or publication of this article. DATA AVAILABILITY STATEMENT All data associated with this study is available in the main text or the . Supporting Information Filename Description dme70169-sup-0001-FigureS1.pdfPDF document, 335.1 KB Figure S1: Capillary electrophoresis peak map. (A) rs5182, (B) rs11137037, (C) rs2442598, (D) rs1800469 and (E) rs3025020.
OsCDPK24 and OsCDPK28 phosphorylate heat shock factor OsHSFA4d to orchestrate abiotic and biotic stress responses in rice - Nature Communications
Abstract Global warming impacts crop production and increases crop disease. It is commonly known that heat stress (HS) caused by extreme high temperature induces HS responses but suppresses disease resistance in plants. However, the molecular basis of this trade-off remains largely unknown. Here, we report that OsHsfA4d shows strongest induction upon HS and pathogen infection among Heat Shock Factors (HSFs) in rice.
Influence Mechanism of Spatial Variability of Permeability Coefficient on Seepage Characteristics of High Core Rockfill Dams: Insights from Numerical Simulations
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Exploring the Relationship between Serum IL-33 Levels and Clinical Manifestations in Systemic Lupus Erythematosus: A Comprehensive Analysis
Introduction Systemic lupus erythematosus (SLE) is a complex autoimmune disorder characterised by diverse clinical manifestations and unpredictable disease progression (Harley and Sawalha, 2022; Aldakheel et al, 2023). Despite extensive research conducted on SLE, the exact mechanisms underlying its origin and progression remain poorly understood.
Study on the Impact of Seepage Filtration Under Wet-Dry Cycles on the Stability of Mudstone Limestone Slopes
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Mercury Fraction and Transformation in Sediment Cores of the Eutrophic Estuary in Northern Taiwan
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Rice transcription factor bHLH25 confers resistance to multiple diseases by sensing H2O2 - Cell Research
Abstract Hydrogen peroxide (H2O2) is a ubiquitous signal regulating many biological processes, including innate immunity, in all eukaryotes. However, it remains largely unknown that how transcription factors directly sense H2O2 in eukaryotes. Here, we report that rice basic/helix-loop-helix transcription factor bHLH25 directly senses H2O2 to confer resistance to multiple diseases caused by fungi or bacteria.
Freeze-Thaw Damage Characteristics of Soil-Rock Mixtures in Open-Pit Coal Mines and Stability Analysis of Slopes in Discharge Sites Based on Partial Flow Code
1. Introduction As a special geological material mixed with soil and rocks, the soil–rock mixture is widely found in mountainous areas, roads, and open-pit mines, and its unique physical and mechanical properties are different from those of soil and rock, with many influencing factors.
Characterization and Concentration Prediction of Dust Pollution in Open-Pit Coal Mines
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
First-principles study on the structure and stability of defect complexes and clusters in nitrogen-doped Czochralski silicon
First-principles study on the structure and stability of defect complexes and clusters in nitrogen-doped Czochralski silicon In Czochralski (CZ)-Si, crystal originated particles (COPs) and bulk micro-defects (BMDs), which are primarily composed of voids and O-precipitates (OPs), respectively, have profound influences on the properties of wafers and resultant electronic devices. Impurity doping can be an effective approach to adjusting the concentrations of COPs and BMDs as desired.
Identification and Mining of Functional Components of Polyphenols in Fruits of Malus Germplasm Resources Based on Multivariate Analysis
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Dynamic Changes in Polyphenols in Fruit Development of Red Flesh Apple ‘Hongxun 2’
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Dynamics of epitranscriptomes uncover translational reprogramming directed by ac4C in rice during pathogen infection - Nature Plants
Abstract Messenger RNA modifications play pivotal roles in RNA biology, but comprehensive landscape changes of epitranscriptomes remain largely unknown in plant immune response. Here we report translational reprogramming directed by ac4C mRNA modification upon pathogen challenge. We first investigate the dynamics of translatomes and epitranscriptomes and uncover that the change in ac4C at single-base resolution promotes translational reprogramming upon Magnaporthe oryzae infection.
Analysis of Aroma Characteristics of ‘Binzi’ and ‘Xiangguo’ Apple-Ancient Cultivars in China
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Metagenomic analysis reveals high diversity of gut viromes in yaks (Bos grunniens) from the Qinghai-Tibet Plateau - Communications Biology
Abstract The Qinghai-Tibet Plateau (QTP), renowned for its exceptional biological diversity, is home to numerous endemic species. However, research on the virology of vulnerable vertebrates like yaks remains limited. In this study, our objective was to use metagenomics to provide a comprehensive understanding of the diversity and evolution of the gut virome in yak populations across different regions of the QTP.
Efficient Spectral Broadening and Few‐Cycle Pulse Generation with Multiple Thin Liquid Films
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description lpor202301191-sup-0001-SuppMat.docx281.8 KB Supporting Information References 1, , , , , , Phys. Rev. Lett. 2003, 90, 233003. 2, , , , , , , , , , , , Nature 2010, 466, 739. 3, , , , Phys. Rev. Lett. 2004, 92, 133005. 4, , , , , , , , , Nat. Commun. 2020, 11, 2748. 5, , Ann. Rev. Phys. Chem. 2008, 59, 463. 6, , Rev. Mod. Phys. 2000, 72, 545. 7, , Rev. Mod. Phys. 2009, 81, 163. 8, , , Appl. Phys. Lett.
Fine-tuning of IPA1 transactivation activity by E3 ligase IPI7-mediated non-proteolytic K29-ubiquitination during Magnaporthe oryzae infection - Nature Communications
Abstract The Ideal Plant Architecture 1 (IPA1) transcription factor promotes rice yield and immunity through phosphorylation at its amino acid residue Ser163 as a switch. Although phosphorylated IPA1 mimic, IPA1(S163D), directly targets the promoter of immune response gene WRKY45, it cannot activate its expression.
A Methodology for Modeling a Multi-Dimensional Joint Distribution of Parameters Based on Small-Sample Data, and Its Application in High Rockfill Dams
1. Introduction More than 98,000 reservoir dams have been built in China, with embankment dams accounting for about 93% of this total [1]. With the deepening of hydropower development in China, a large number of high rockfill dam projects have been put into construction and operation.
Influence Analysis of Material Parameter Uncertainties on the Stability Safety Factor of Concrete Gravity Dams: A Probabilistic Method
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Sequential transcriptional waves and NF-κB-driven chromatin remodeling direct drug-induced dedifferentiation in cancer
New Results Sequential transcriptional waves and NF-κB-driven chromatin remodeling direct drug-induced dedifferentiation in cancer Yapeng Su, Chunmei Liu, Xiang Lu, Guideng Li, Shiqun Shao, Yan Kong, Jihoon Lee, Rachel Ng, Stephanie Wong, Lidia Robert, Charles Warden, Victoria Liu, Jie Chen, Zhuo Wang, Guangrong Qin, Yin Tang, Hanjun Cheng, Alphonsus Ng, Songming Peng, Min Xue, Dazy Johnson, Yu Xu, Jinhui Wang, Xiwei Wu, Ilya Shmulevich, Qihui Shi, Raphael Levine, Antoni Ribas, David...
Slope Stability Analysis of Rockfill Embankments Considering Stress-Dependent Spatial Variability in Friction Angle of Granular Materials
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Glass modified Na0.5Bi0.5TiO3-based energy-storage ceramics for high-temperature applications at low/moderate electric fields
Glass modified Na0.5Bi0.5TiO3-based energy-storage ceramics for high-temperature applications at low/moderate electric fields Given the necessity to spur progress of energy-storage equipment for high pulse power systems, it is of great concern to tackle the critical issue for concurrently optimizing energy storage density (Wrec), efffciency (η) and stability at elevated temperature in Na0.5Bi0.5TiO3-based ceramics.
Umbrella review of risk factors for inflammatory bowel disease: a study protocol
Inflammatory bowel disease Risk Factors Systematic Review http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use...
Discovery of novel RNA viruses through analysis of fungi-associated next-generation sequencing data - BMC Genomics
To discover novel fungal-associated viruses, we downloaded 236 available libraries from the SRA database, corresponding to 32 fungal species (Supplementary Table 1). Pfastq-dump v0.1.6 (https://github.com/inutano/pfastq-dump) was used to convert SRA format files to fastq format files. Subsequently, Bowtie2 v2.4.5 [26] was employed to remove host sequences.
A Method for Evaluating Systematic Risk in Dams with Random Field Theory
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Immediate versus delayed single blastocyst transfer following the first stimulated IVF cycle in the freeze-all strategy: a study protocol for a randomised controlled trial
Ethics and dissemination Since FET in HRT cycles is a common practice in IVF centres, and there is no agreement regarding the time interval between stimulated IVF and subsequent FET in the literature, there are no predefined criteria for premature termination in this study. There will be no interim analysis during the study.
Performance of a High-Speed Pyroelectric Receiver as Cryogen-Free Detector for Terahertz Absorption Spectroscopy Measurements
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The characteristics of HER2 low-expressing breast cancer: a China single-center real-world data analysis
Human epidermal growth factor receptor-2 (HER2) is a receptor on the cell surface that is activated after receiving specific signals, transmits information into cells and regulates cell growth and proliferation. In breast cancer cells, HER2 also plays an important role in regulating cell proliferation, survival, differentiation and migration [1]. Slamon et al. first reported in 1987 that HER2 amplification was associated with poor prognosis of breast cancer [2].
Research Progress on Cuttings of Malus Rootstock Resources in China
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Magnaporthe oryzae effector MoSPAB1 directly activates rice Bsr-d1 expression to facilitate pathogenesis - Nature Communications
Abstract Fungal pathogens typically use secreted effector proteins to suppress host immune activators to facilitate invasion. However, there is rarely evidence supporting the idea that fungal secretory proteins contribute to pathogenesis by transactivating host genes that suppress defense. We previously found that pathogen Magnaporthe oryzae induces rice Bsr-d1 to facilitate infection and hypothesized that a fungal effector mediates this induction. Here, we report that MoSPAB1 secreted by M.
Large optical conductivity of Fermi arc states in Weyl and Dirac semimetal nanowires
We theoretically study the band structure and optical conductivity in the Weyl and Dirac semimetal nanowires. It is found that the Fermi arc states play a crucial role in the optical conductivity. The optical conductivity shows an anisotropic dependence on the optical polarization axis. The qualitative anisotropy is attributed to the underlying band structure and distinct optical selection rules.
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