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Xiangyin Tan

As seen in: Nature, Cell Metabolism
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Articles

A lactate–α-ketoglutarate metabolic circuit in tumor-infiltrating regulatory T cells accelerates tumor progression by inducing NK cell senescence

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By Tiezhu Shi, Yufeng Ding, Ying Chen, Xiangyin Tan, Fangfang Qu, Dongwei Xu, Xinyu Liu, Yixue Li, Yan-Fang Liu, Xiaolin Zhang, Guanzhen Yu, Jialiang Shao, Xiongjun Wang
| Nature Verified
Abstract Regulatory T (Treg) cells prevent autoimmune diseases but limit antitumor immunity. Tumor‑infiltrating Treg (Ti‑Treg) cells exhibit metabolic traits as potential antitumor targets. Here, we find that Ti-Treg cells upregulate glutamate dehydrogenase 1 (GDH1), increasing α-ketoglutarate (α-KG) levels. Elevated GDH1 in Ti-Treg cells accelerates tumor progression.
Open in Who Shared Issue with article?

Xylulose 5-phosphate fosters sustained antitumor activity of progenitor-like exhausted SLC35E2+ CD8+ T effector cells

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By Tiezhu Shi, Jialiang Shao, Yufeng Ding, Hong Tang, Xiangyin Tan, Sisi Zhou, Shaoqing Yu, Xiang Wang, Guanzhen Yu, Ninghan Feng, Xiongjun Wang
| Cell Metabolism Verified
Open in Who Shared Issue with article?
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