Xianxu Zeng

Abstract The tumorigenesis and progression of conventional cervical squamous cell carcinoma generally follow a well-defined cascade: from normal cervix uteri to high-grade cervical intraepithelial neoplasia (precancer), cervical carcinoma in situ, and ultimately invasive cervical carcinoma. However, biomarkers and targets that reflect tumor evolution during CSCC progression at different time points within the same patient remain lacking.

Introduction Hypothyroidism is one of the most common endocrine disorders, and is defined as a systemic metabolic syndrome resulting from a reduction in the synthesis or secretion of thyroid hormones for a variety of etiologies (1, 2). It affects approximately 3-5% of pregnant women, with its prevalence being even higher in iodine-deficient areas due to pregnancy-induced alterations in hormone levels and iodine metabolism which can disrupt maternal thyroid function (3–5).

INTRODUCTION The role of automation in cytopathology, particularly cervical smears, continues to be of great importance as its capabilities and limitations are thoroughly examined and established. To date, for cervical pathology, many automated methods currently exist, such as the PAPNET system (Neuromedical Systems), the AutoPap 300 QC device (NeoPath, Inc.), the ThinPrep imaging system (Hologic), the AIATBS system, and the AICyte system (Ruiqian Technologies Company, Ltd.).