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Comparative efficacy of therapeutic strategies for recurrent or refractory glioblastoma: a systematic review and network meta-analysis
Abstract Background: Recurrent or refractory glioblastoma has a poor prognosis, and no universally accepted standard treatment has been established. Randomized evidence is fragmented, making pairwise comparisons insufficient. This study aimed to compare available treatments using a frequentist network meta-analysis.
The effect of type 2 diabetes genetic predisposition on non-cardiovascular comorbidities - Nature Communications
Abstract Type 2 diabetes is associated with a range of non-cardiovascular non-oncologic comorbidities. To move beyond associations and evaluate causal effects between type 2 diabetes genetic predisposition and 21 comorbidities, we apply Mendelian randomization analysis using genome-wide association studies across multiple genetic ancestries.
Polygenic risk score for type 2 diabetes shows context-dependent effects across populations - Nature Communications
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Abstract Polygenic risk scores hold prognostic value for identifying individuals at higher risk of type 2 diabetes. However, further characterization is needed to understand the generalizability of type 2 diabetes polygenic risk scores in diverse populations across various contexts.
By Boya Guo, Daeeun Kim, Zhe Wang, Austin T. Hilliard, Ran Tao, Yujie Wang, Nikita Pozdeyev, Frederik F. Stæger, Chaojie Yang, Jonathan A Shortt, Laura Wiley, Maggie A. Stanislawski, Lea K. Davis, Megan Shuey, Marit E. Jørgensen, Peter Bjerregaard, Torben Frøstrup Hansen, Ida Moltke, Xianyong Yin, Xiang Zhou, Kyong-Mi Chang, Shoa L. Clarke, Rodrigo Guarischi-Sousa, Philip S. Tsao, Steven Buyske, Mariaelisa Graff, Laura M. Raffield, Quan Sun, Simin Liu, JoAnn E. Manson, Joann Manson, Christopher A. Haiman, Karen L. Mohlke, Penny Gordon-Larsen, Anders Albrechtsen, Michael Boehnke, Stephen S. Rich, Ani W Manichaikul, Jerome I. Rotter, Chris R. Gignoux, Themistocles L. Assimes, Ulrike Peters, Charles Kooperberg, Heather M. Highland
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