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Xianyun Gao

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Articles

Glucose-responsive probiotics for glycaemic modulation in mice and monkeys

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By Ningzi Guan, Deqiang Kong, Lingxue Niu, Yang Zhou, Guiling Yu, Tian Gao, Mengyao Liu, Wenbo Ma, Jianli Yin, Shangang Zhao, Haifeng Ye, Xianyun Gao, Yiyu Jin
| Nature Verified
Abstract Sustained and controlled delivery of glucose-lowering agents using engineered designer cells is recognized as an effective strategy for diabetes therapy1. However, current technologies rely on external signal control or have been programmed into mammalian cells using synthetic gene networks, which pose safety concerns arising from transplantation2,3.
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