Xianzhuang Liu on Muck Rack

Xianzhuang Liu

As seen in: Nature
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Self-assembled chamber-like cardiac organoids for modeling cardiac chamber formation and cardiotoxicity assessment

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By Xinle Zou, Fanwen Wang, Huilin Zheng, Tianci Kong, Rui Jiang, Yingying Guo, Yu Liang, Hanqing Zhao, Bo Wang, Duanqing Pei, Xianzhuang Liu
| Nature
Abstract The human heart remains a central focus of biomedical research, yet capturing early chamber morphogenesis in vitro with structural and functional fidelity remains challenging. Here we show the generation of chamber-like cardiac organoids (CCOs) from human pluripotent stem cells that reproduce key features of heart chamber development. CCO formation is orchestrated by coordinated FGF, WNT, BMP, RA, and AA signaling, and regulated by transcription factors including HAND1, TFAP2B and NR2F2.
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