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Yingying Guo on Muck Rack

Yingying Guo

As seen in: Color Research & Application, Nature, Wiley Online Library, ScienceDirect, Annals of the Rheumatic Diseases, Frontiers, Frontiers in Immunology, Journal of Business Research, MDPI, Technovation and
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Articles

Platelet factor 4 in cognitive, immune and hematopoietic aging: emerging evidence and translational challenges

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By Yingying Guo, Zihua Liu, Weiwei Lu, Hao Zhuo, Zhicheng Wang, Xiaoning Wang
| Frontiers in Immunology
Abstract Platelet Factor 4 (PF4) is a CXC chemokine abundantly sequestered within platelet α-granules. Its modulatory roles in age-related dysfunction across cognitive, immune, and hematopoietic systems have garnered increasing research attention in recent years. PF4 modulates an array of biological pathways associated with the attenuation of aging-related cellular defects; these pathways are activated by physical activity, young plasma exposure, and Klotho-related signaling cascades.
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Implicaciones pronósticas de la disfunción microvascular coronaria en el IAMCEST con y sin síndrome metabólico

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By Qian Guo, Yingying Guo, Shutian Shi
| Dialnet - Universidad de La Rioja
español Introducción y objetivos El síndrome metabólico (SMet) se asocia con la disfunción microvascular coronaria (DMC) y ambas entidades aumentan el riesgo de episodios cardiovasculares tras un infarto agudo de miocardio con elevación del segmento ST (IAMCEST). Sin embargo, la importancia de la DMC en pacientes con IAMCEST y SMet sigue sin estar clara.
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Self-assembled chamber-like cardiac organoids for modeling cardiac chamber formation and cardiotoxicity assessment

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By Xinle Zou, Fanwen Wang, Huilin Zheng, Tianci Kong, Rui Jiang, Yingying Guo, Yu Liang, Hanqing Zhao, Bo Wang, Duanqing Pei, Xianzhuang Liu
| Nature Verified
Abstract The human heart remains a central focus of biomedical research, yet capturing early chamber morphogenesis in vitro with structural and functional fidelity remains challenging. Here we show the generation of chamber-like cardiac organoids (CCOs) from human pluripotent stem cells that reproduce key features of heart chamber development. CCO formation is orchestrated by coordinated FGF, WNT, BMP, RA, and AA signaling, and regulated by transcription factors including HAND1, TFAP2B and NR2F2.
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