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STEP: Spatial Transcriptomics Embedding Procedure for Multi-scale Biological Heterogeneities Revelation in Multiple Samples
Abstract In the realm of spatially resolved transcriptomics (SRT) and single-cell RNA sequencing (scRNA-seq), addressing the intricacies of complex tissues, integration across non-contiguous sections, and scalability to diverse data resolutions remain paramount challenges. We introduce STEP (Spatial Transcriptomics Embedding Procedure), a novel foundation AI architecture for SRT data, elucidating the nuanced correspondence between biological heterogeneity and data characteristics.
COVID-19 and influenza infections mediate distinct pulmonary cellular and transcriptomic changes - Communications Biology
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Abstract SARS-CoV-2 infection can cause persistent respiratory sequelae. However, the underlying mechanisms remain unclear. Here we report that sub-lethally infected K18-human ACE2 mice show patchy pneumonia associated with histiocytic inflammation and collagen deposition at 21 and 45 days post infection (DPI).
By Chenxiao Wang, Zhe Zhang, Xiao-Ming Yin, Nicholas J. Maness, Robert Blair, Jay Kolls Verified, Derek A. Pociask
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Nature
Verified
Insights from a high-fat diet fed mouse model with a humanized liver
Chow versus refined control diet In C57BL/6 mice, high-fat feeding using purified ingredient diets induces insulin resistance and glucose intolerance within 8 weeks [14–16, 30]. Nutrients from plant sources present in chow diets and absent in purified ingredient diets influence multiple traits, including food intake, hormone levels (insulin, leptin), and body and adipose tissue weight [31, 32].
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