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Articles by Xiaocui Huang
Lineage structure and penicillin-binding protein variability in clinical Streptococcus pneumoniae isolates from Southwest China exhibiting reduced susceptibility to penicillin
Abstract Background: Reduced susceptibility to penicillin in Streptococcus pneumoniae is mediated primarily by alterations in penicillin-binding proteins (PBPs) and often coexists with multidrug resistance within successful lineages. The region-specific genomic characterization of clinically relevant pneumococci with reduced penicillin susceptibility in Southwest China remains limited. Methods: We performed whole-genome sequencing of 204 clinical S.
Host insulin hijacking by a nematode receptor mediates developmental plasticity and sex ratio shifts
Abstract Parasitic nematodes encode a limited repertoire of insulin/insulin-like peptides (INS/ILPs) which are expressed primarily in free-living stages, suggesting that host insulin may serve as a critical agonist during parasitism. In this study, we demonstrate that mammalian parasitic nematodes exploit host insulin via their conserved insulin/insulin-like growth factor receptor (IGFR/DAF-2) to drive infection and reproduction in vitro and in vivo.
Screening and Application of DNA Aptamers for Heparin-Binding Protein
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Low-Background Signal-On Homogeneous Electrochemiluminescence Biosensor for Hepatitis B Virus Detection Based on the Regulation of the Length of DNA Modified on the Nanoparticles by CRISPR/Cas12a and Hybridization Chain Reaction
Download Hi-Res ImageDownload to MS-PowerPointCite This:Anal. Chem. 2023, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Ultrasensitive Electrochemiluminescence Biosensor for Nuclear Factor kappa B p50 based on Proximity Hybridization-induced Hybridization Chain Reaction
Ultrasensitive Electrochemiluminescence Biosensor for Nuclear Factor kappa B p50 based on Proximity Hybridization-induced Hybridization Chain Reaction Nuclear factor kappa B p50 (NF-κB p50) induces various biological processes.
A label-free and signal-on electrochemical aptasensor for ultrasensitive kanamycin detection based on exonuclease recycling cleavage
Taking advantage of the preferential exodeoxyribonuclease activity of exonuclease III (Exo III) in combination with the highly specific recognition of aptamers, a label-free and signal-on electrochemical aptasensor for ultrasensitive kanamycin (Kan) detection has been proposed based on aptamer triggered Exo III recycling cleavage.
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