Xiaojing Yang on Muck Rack

Xiaojing Yang

San Diego
As seen in: Environmental Health Perspectives, Nature, Wiley Online Library, Memory Studies, MDPI, ACS Publications, BMC Cancer, Science Magazine, Royal Society of Chemistry, Cell Press and
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Articles

Preclinical evaluation of antisense oligonucleotide therapy in a mouse model of HNRNPH2 -related neurodevelopmental disorder

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By Ruizeng Yang, Naseeb Kaur Malhi, Alessandro Umbach, Ane Korff, Xiaojing Yang, Ozan Ozdemir, Yong-Dong Wang, Tushar Patni, Alfonso Lavado, Anoop Kavirayani, Joseph Ochaba, Berit Powers, C. Frank Bennett, Hong Joo Kim, J. Paul Taylor, Ananya Samanta
| Science Magazine
Editor’s summary HNRNPH1 and HNRNPH2 are closely related RNA binding proteins with similar roles in RNA processing and splicing during neurogenesis. De novo mutations in the HNRNPH2 gene cause a rare and severe neurodevelopmental disorder for which there is currently no treatment. Here, Korff et al. designed gapmer antisense oligonucleotides (ASOs) to target Hnrnph2 and show that a knockdown of Hnrnph2 mRNA up-regulated Hnrnph1 mRNA and protein.
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Prefusion-stabilized Hantaan virus glycoprotein nucleic acid vaccine elicits potent neutralizing antibody responses via germinal center activation

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By Wei Ye, Yuan Wang, Qiqi Yang, Chuantao Ye, Jing Wei, Jiawei Pei, Xiaojing Yang, Xiaolei Jin, Hongwei Ma, He Liu, Liang Zhang, Linfeng Cheng, Yangchao Dong, Yingfeng Lei, Zhikai Xu, Fanglin Zhang, Yamei Dang, Xuemin Pei, Dongshen Jiang
| Nature
Abstract Old World orthohantaviruses, including Hantaan virus (HTNV), cause hemorrhagic fever with renal syndrome (HFRS) in Eurasia. Available inactivated vaccines often induce low neutralizing antibodies and short-term protection. We evaluated nucleic acid vaccines expressing a prefusion-stabilized HTNV glycoprotein in female BALB/c mice.
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Iron-Rich Particles Drive Pulmonary Toxicity of Coal Combustion-Derived Fine Particles via Transferrin Receptor-Mediated Ferroptosis

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By Xiaojing Yang, Yuxiang Cao, Miao Xu
| dx.doi.org
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