Ruizeng Yang on Muck Rack

Ruizeng Yang

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Articles

Diabetes-induced TREM2–endothelial cell signaling impairs ischemic vascular repair

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By Ruizeng Yang, Naseeb Kaur Malhi, Alessandro Umbach, Yingjun Luo, Muxi Chen, Xiaofang Tang, Dongqiang Yuan, Rahuljeet Singh Chadha, Alonso Tapia, Xuejing Liu, Meirigeng Qi, Marpadga A. Reddy, Jiawei Sun, James Otto, Lu Wei, John P. Cooke, Esak Lee, Rama Natarajan, Shufan Yin, Kevin W. Sou
| Science Magazine Verified
Editor’s summary Diabetes can lead to peripheral artery disease (PAD), and how individual cell types across tissues contribute to disease progression has been difficult to understand. Malhi et al. focused on endothelial cells and macrophages from humans with and without type 2 diabetes to find that triggering receptor expressed on myeloid cells 2 (TREM2) was one of the top genes expressed in mononuclear phagocytes. This expression was associated with increased TREM2 ligands in endothelial cells.
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Programming peripheral artery disease in diabetes

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By Ruizeng Yang, Naseeb Kaur Malhi, Alessandro Umbach
| Science Magazine Verified
Abstract Reprogrammed TREM2+ macrophages drive nonresolving inflammation in peripheral artery disease associated with type 2 diabetes (Malhi et al., this issue). Access the full article View all access options to continue reading this article. REFERENCES AND NOTES 1 J. A. Beckman, F. Paneni, F. Cosentino, M. A. Creager, Diabetes and vascular disease: Pathophysiology, clinical consequences, and medical therapy: Part II. Eur. Heart J. 34, 2444–2452 (2013). 2 B. H. Annex, J. P.
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Phase separation–based HTS identifies cobimetinib as a YAP-TEAD inhibitor that suppresses hyperactivated YAP-induced cancer progression

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By Ruizeng Yang, Naseeb Kaur Malhi, Alessandro Umbach, Liqiao Hu, Jing Wang, Jia Wang, Liang Yuan, Mengying Wu, Wentao Yu, Peihao Chen, Xiaoli Lu, Haijiao Zhang, Haoran Gao, Xiaodong Wang, Yang Sun, Jinjin Xu, Jing Huang, Hu Zhou, Jidong Zhu, Fang Wei, Fangzheng Hu, Haoen Zhang
| Science Magazine Verified
Editor’s summary YAP/TAZ are key effectors of the Hippo pathway, which regulates an array of biological processes, including cell proliferation, survival, apoptosis, and tissue homeostasis. The binding of YAP/TAZ to the transcription factor TEAD induces the transcription of genes that promote cancer growth. Yang et al.
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