Xiaole Yin

Abstract To assure the safe distribution of drinking water, it is critical to identify and limit adaptations that allow microorganisms to thrive in an oligotrophic system under disinfectant stress. Microbial adaptive responses are determined using RNA–based differential transcriptomics, which cannot be performed in environmental settings due to a lack of a baseline.

Abstract Fecal coprolites preserve ancient microbiomes and are a potential source of extinct but highly efficacious antimicrobial peptides (AMPs). Here, we develop AMPLiT (AMP Lightweight Identification Tool), an efficient tool deployable to portable hardware for AMP screening in metagenomic datasets. AMPLiT demonstrates AUPRC performances of 0.9486 ± 0.0003 and reasonable overall training time of 3200 ± 53 s.

Abstract Click to copy section linkSection link copied! Targeted perturbation of redox balance through concurrent elevation of reactive oxygen species (ROS) production and glutathione (GSH) depletion has emerged as a therapeutic paradigm for triggering tumor cell apoptosis. Nevertheless, the conventional single-agent system demonstrates limited therapeutic efficacy due to insufficient oxidative stress amplification within tumor cells.